Document Detail


Malaria in India: the center for the study of complex malaria in India.
MedLine Citation:
PMID:  22142788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malaria is a major public health problem in India and one which contributes significantly to the overall malaria burden in Southeast Asia. The National Vector Borne Disease Control Program of India reported ∼1.6 million cases and ∼1100 malaria deaths in 2009. Some experts argue that this is a serious underestimation and that the actual number of malaria cases per year is likely between 9 and 50 times greater, with an approximate 13-fold underestimation of malaria-related mortality. The difficulty in making these estimations is further exacerbated by (i) highly variable malaria eco-epidemiological profiles, (ii) the transmission and overlap of multiple Plasmodium species and Anopheles vectors, (iii) increasing antimalarial drug resistance and insecticide resistance, and (iv) the impact of climate change on each of these variables. Simply stated, the burden of malaria in India is complex. Here we describe plans for a Center for the Study of Complex Malaria in India (CSCMi), one of ten International Centers of Excellence in Malaria Research (ICEMRs) located in malarious regions of the world recently funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health. The CSCMi is a close partnership between Indian and United States scientists, and aims to address major gaps in our understanding of the complexity of malaria in India, including changing patterns of epidemiology, vector biology and control, drug resistance, and parasite genomics. We hope that such a multidisciplinary approach that integrates clinical and field studies with laboratory, molecular, and genomic methods will provide a powerful combination for malaria control and prevention in India.
Authors:
Aparup Das; Anupkumar R Anvikar; Lauren J Cator; Ramesh C Dhiman; Alex Eapen; Neelima Mishra; Bhupinder N Nagpal; Nutan Nanda; Kamaraju Raghavendra; Andrew F Read; Surya K Sharma; Om P Singh; Vineeta Singh; Photini Sinnis; Harish C Srivastava; Steven A Sullivan; Patrick L Sutton; Matthew B Thomas; Jane M Carlton; Neena Valecha
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-28
Journal Detail:
Title:  Acta tropica     Volume:  121     ISSN:  1873-6254     ISO Abbreviation:  Acta Trop.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-06-19     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
National Institute of Malaria Research, Indian Council of Medical Research, New Delhi, India. aparup@mrcindia.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Anopheles / parasitology
Antimalarials / pharmacology
Climate
Disease Transmission, Infectious / prevention & control
Drug Resistance, Multiple
Ecology
Genetic Variation
Genome, Protozoan*
Health Services Research / organization & administration
Humans
India / epidemiology
Insect Vectors / parasitology*
International Cooperation
Malaria / drug therapy,  epidemiology,  parasitology,  prevention & control*
National Health Programs / economics,  organization & administration*
Plasmodium / genetics*,  pathogenicity
Grant Support
ID/Acronym/Agency:
3D43TW007884-03S1/TW/FIC NIH HHS; U19 AI089676-01/AI/NIAID NIH HHS; U19AI089676/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antimalarials
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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