| Malaria: host-pathogen interactions, immunopathological complications and therapy. | |
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MedLine Citation:
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PMID: 22276399 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Malaria is a global tropical disease causing more than 1 million deaths and 300 million clinical cases every year. It is caused by parasites from the genus Plasmodium and is transmitted by Anopheles mosquitoes. Approximately 3 billion people live in malaria-endemic regions and a majority of them are infected. In this review, we discuss the life cycle of the parasite, the complex interactions with the human host and the ensuing immune reactions and complications. The immune system plays a dual role in malaria, by providing life-saving immunity against the parasite, but also by causing often lethal complications in a number of patients. Cytokines, chemokines and proteases are key players in the immunopathological complications, and we propose immunomodulation with dexamethasone as a promising strategy for the therapy of malaria-associated acute respiratory distress syndrome. |
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Authors:
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P E Van Den Steen; K Deroost; N Geurts; H Heremans; J Van Damme; G Opdenakker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Verhandelingen - Koninklijke Academie voor Geneeskunde van België Volume: 73 ISSN: 0302-6469 ISO Abbreviation: Verh. K. Acad. Geneeskd. Belg. Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413210 Medline TA: Verh K Acad Geneeskd Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 123-51 Citation Subset: IM |
Affiliation:
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Laboratory of Immunobiology, Rega Institute for Medical Research--KULeuven, Minderbroedersstraat 10--B 3000 Leuven. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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