Document Detail


Malaria antibody persistence correlates with duration of exposure.
MedLine Citation:
PMID:  23134513     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Objectives  In Australia, the risk of transfusion-transmitted malaria is managed through the identification of 'at-risk' donors, antibody screening enzyme-linked immunoassay (EIA) and, if reactive, exclusion from fresh blood component manufacture. Donor management depends on the duration of exposure in malarious regions (>6 months: 'Resident', <6 months: 'Visitor') or a history of malaria diagnosis. We analysed antibody testing and demographic data to investigate antibody persistence dynamics. To assess the yield from retesting 3 years after an initial EIA reactive result, we estimated the proportion of donors who would become non-reactive over this period. Materials and Methods  Test results and demographic data from donors who were malaria EIA reactive were analysed. Time since possible exposure was estimated and antibody survival modelled. Results  Among seroreverters, the time since last possible exposure was significantly shorter in 'Visitors' than in 'Residents'. The antibody survival modelling predicted 20% of previously EIA reactive 'Visitors', but only 2% of 'Residents' would become non-reactive within 3 years of their first reactive EIA. Conclusion  Antibody persistence in donors correlates with exposure category, with semi-immune 'Residents' maintaining detectable antibodies significantly longer than non-immune 'Visitors'.
Authors:
H M Faddy; C R Seed; M J Faddy; R L Flower; R J Harley
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Vox sanguinis     Volume:  -     ISSN:  1423-0410     ISO Abbreviation:  Vox Sang.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion.
Affiliation:
Research and Development, Australian Red Cross Blood Service, Brisbane, Qld, Australia Medical Services, Australian Red Cross Blood Service, Perth, WA, Australia Mathematical Sciences, Queensland University of Technology, Brisbane, Qld, Australia Medical Services, Australian Red Cross Blood Service, Brisbane, Qld, Australia.
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