| Malaria and HIV co-infection: available evidence, gaps and possible interventions. | |
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MedLine Citation:
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PMID: 15214286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To review the evidence of association between malaria and HIV/AIDS co-infection for purposes of developing strategies for malaria control. DESIGN: Desktop review of literature. SETTING: Harare, Zimbabwe. MAIN OUTCOME MEASURES: Response to treatment, development of severe malaria, malarial immunological response in HIV/AIDS positive people and incidence of malaria in HIV/AIDS positive individuals. RESULTS: HIV-1 infection increases the incidence of Plasmodium falciparum parasitaemia and is associated with the development of severe malaria, commonly anaemia, cerebral malaria and high parasite density (OR = 2.56; 95% CI = 1.53 to 4.29; p < 0.001). The efficacy of chloroquine and sulphadoxine-pyrimethamine in reducing placental malaria in HIV-1 positive pregnant women was impaired compared to HIV-1 negative pregnant women. However, the situation in non-gravid HIV-1 positive people as regards efficacy of chloroquine and sulphadoxine-pyrimethamine prophylaxis is not known. Also not known is the relationship between malaria parasitaemia without symptoms and HIV-1 infection, the results of which may provide useful information regarding malaria control and prevention in HIV-1 positive people. CONCLUSIONS: HIV-1 positive people staying in malaria endemic areas are at risk of developing severe malaria. Malaria prevention using insecticide-treated bednets and indoor residual house spraying may be the best available options for these people. Chloroquine and sulphadoxine-pyrimethamine prophylaxis require further studies to verify their efficacy, in the presence of HIV-1/AIDS infection. |
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Authors:
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J Chirenda; S Murugasampillay |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Central African journal of medicine Volume: 49 ISSN: 0008-9176 ISO Abbreviation: Cent Afr J Med Publication Date: 2003 May-Jun |
Date Detail:
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Created Date: 2004-06-24 Completed Date: 2004-08-26 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0372566 Medline TA: Cent Afr J Med Country: Zimbabwe |
Other Details:
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Languages: eng Pagination: 66-71 Citation Subset: IM |
Affiliation:
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Department of Community Medicine-MPH Programme, University of Zimbabwe, PO Box A1114, Avondale, Harare, Zimbabwe. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Protozoan / immunology Communicable Disease Control Comorbidity HIV Infections / complications, epidemiology*, prevention & control Humans Incidence Malaria, Falciparum / complications, epidemiology*, prevention & control Plasmodium falciparum / immunology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Protozoan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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