Document Detail

Malabsorption syndrome associated with ulceration of the stomach and small bowel caused by chronic intestinal ischemia in a patient with hyperhomocysteinemia.
MedLine Citation:
PMID:  9179139     Owner:  NLM     Status:  MEDLINE    
We describe a 39-year-old woman with an 8-month history of abdominal pain, diarrhea, and weight loss. Clinical and laboratory evaluation indicated the presence of a malabsorption syndrome. Endoscopy revealed multiple gastric ulcerations and an abnormal "picture" of the duodenal mucosa. At duodenal biopsy, necrosis confined to the distal parts of the enteric villi and a polymorphonuclear leukocyte response were found. Further evaluation revealed intestinal ischemia as a result of mesenteric atherosclerosis. After a revascularization procedure was performed, the symptoms disappeared. The macroscopic and microscopic picture of the bowel normalized. In our search for risk factors of atherosclerosis, we found a substantially increased basal plasma homocysteine concentration. This case suggests that hyperhomocysteinemia may have a causal role in the development of symptomatic, premature atherosclerosis of the mesenteric circulation.
R C Bakker; D P Brandjes; P Snel; J A Lawson; J Lindeman; D Batchelor
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  72     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-16     Completed Date:  1997-07-16     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  546-50     Citation Subset:  AIM; IM    
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MeSH Terms
Chronic Disease
Duodenal Ulcer / complications*,  pathology
Homocysteine / blood*
Intestines / blood supply*,  pathology
Ischemia / complications*,  pathology
Malabsorption Syndromes / etiology*,  pathology
Splanchnic Circulation
Stomach Ulcer / complications*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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