Document Detail

Making a zebrafish kidney: a tale of two tubes.
MedLine Citation:
PMID:  12837606     Owner:  NLM     Status:  MEDLINE    
The kidney can be thought of as the pairing of two tubes: an epithelial tube (the nephron), carrying filtered blood and engaged in ion and water transport; and endothelial tubes (the blood vessels), delivering blood and carrying away recovered solute. The development of the nephron presents several interesting questions. How does an epithelial tube form and how is it patterned into functionally distinct components and segments? What guides the interaction between the vasculature and kidney epithelia? How are epithelial cell shape and lumen diameter maintained, and what goes wrong when kidney tubules balloon into cysts? Here, I outline the progress that has been made in answering these questions using the zebrafish pronephros as a simple, accessible model of nephron development.
Iain Drummond
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  13     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-09-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-65     Citation Subset:  IM    
Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
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MeSH Terms
Cell Communication / physiology
Cell Differentiation / physiology*
Cell Size / physiology
Epithelial Cells / metabolism*,  ultrastructure
Kidney Diseases, Cystic / etiology,  pathology,  physiopathology
Kidney Tubules / blood supply*,  embryology*,  ultrastructure
Renal Artery / embryology*,  ultrastructure
Renal Circulation / physiology
Zebrafish / embryology*,  metabolism
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