Document Detail


Making quantal analysis easier and more accurate.
MedLine Citation:
PMID:  9489888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Problems inherent in applying quantal analysis to synapses are discussed. These include the dispersion in time of the evoked quantal releases and the skew to the right in the distribution of the sizes of the spontaneous miniature potentials. To circumvent some of the problems, quantal analysis was performed at the neuromuscular junction by dividing each individual endplate current (EPC) by the mean miniature endplate current (MEPC) or each individual time integral of the endplate current (integral of EPC) by the mean integral of MEPC. The results were evaluated by comparing the resulting distributions to the predictions of Poisson's law, based on the number of stimuli not followed by a response. The quantal distributions obtained from the integral of MEPCs by this 'point-by-point' were in excellent agreement with these predictions. This method may make quantal analysis easier and more reliable.
Authors:
W Van der Kloot
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  77     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-08     Completed Date:  1998-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Department of Physiology, Health Sciences Center, SUNY, Stony Brook, NY 11794-8661, USA. wvanderkloot@ccmail.sunysb.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Evoked Potentials
Muscle, Skeletal / innervation
Neuromuscular Junction / physiology*
Normal Distribution
Poisson Distribution
Quantum Theory*
Rana pipiens
Sciatic Nerve / physiology
Synaptic Transmission / physiology*
Grant Support
ID/Acronym/Agency:
10320//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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