Document Detail

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo.
MedLine Citation:
PMID:  19129791     Owner:  NLM     Status:  MEDLINE    
Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. Recent advances have uncovered details of the molecular circuits that tightly control cell growth and differentiation in the mammalian embryo from the blastocyst stage, through the establishment of initial anterior-posterior polarity, to gastrulation, when the germ cells are set aside and the three primary germ layers are specified. Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning.
Sebastian J Arnold; Elizabeth J Robertson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-01-08
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  10     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-103     Citation Subset:  IM    
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
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MeSH Terms
Body Patterning / physiology*
Bone Morphogenetic Proteins / genetics,  metabolism
Cell Lineage*
Embryo, Mammalian* / anatomy & histology,  physiology
Signal Transduction / physiology
Smad Proteins / metabolism
Transcription Factors / genetics,  metabolism
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Prdm1 protein, mouse; 0/Prdm14 protein, mouse; 0/Smad Proteins; 0/Transcription Factors

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