Document Detail

Making bacteria behave: new agonists and antagonists of quorum sensing.
MedLine Citation:
PMID:  17518429     Owner:  NLM     Status:  MEDLINE    
Small-molecule agonists and antagonists of bacterial quorum sensing can enhance our understanding of this form of cell-cell communication. A recent effort has discovered effective modulators of the autoinducer-1 circuit for bacterial quorum sensing by the synthesis and evaluation of a small library of aryl-substituted acyl-homoserine lactone analogues. This series highlights the sensitivity to structure of the contrasting responses of agonism and antagonism of the natural signal and identifies an analogue that provokes the same response as the natural signal but at 10-fold lower concentration, a "superagonist".
Megan E Pomianek; M F Semmelhack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ACS chemical biology     Volume:  2     ISSN:  1554-8937     ISO Abbreviation:  ACS Chem. Biol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-23     Completed Date:  2007-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282906     Medline TA:  ACS Chem Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-5     Citation Subset:  IM    
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
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MeSH Terms
4-Butyrolactone / agonists,  analogs & derivatives*,  antagonists & inhibitors
Anti-Bacterial Agents* / chemistry,  pharmacology
Gene Expression Regulation, Bacterial / drug effects
Gram-Negative Bacteria* / drug effects,  genetics,  metabolism
Vibrio fischeri / drug effects,  genetics,  metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Ligands; 1192-20-7/homoserine lactone; 76924-95-3/N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone; 96-48-0/4-Butyrolactone

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