Document Detail

Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
MedLine Citation:
PMID:  15046269     Owner:  NLM     Status:  MEDLINE    
AIM: Antiepileptic drugs (AEDs) are known teratogens. Some specificity between different AEDs has been noted in the literature. The aim was to compare the teratogenic effect of valproic acid (VPA) and carbamazepine (CBZ) in monotherapy. METHODS: Infants exposed to AEDs (n = 1398) in early pregnancy were identified from the Swedish Medical Birth Registry. The number of infants with congenital malformations and exposed to AED was compared with the expected number estimated from all infants born (n = 582656). RESULTS: 90% (1256) of the AED exposed children were exposed to AEDs in monotherapy, 56% were exposed to CBZ and 21% to VPA. The odds ratio (OR) for having a malformation in the AED exposed group was 1.86 [95% confidence interval (95% CI) 1.42-2.44]. Exposure to VPA in monotherapy compared with CBZ in monotherapy gave OR = 2.51 (95% CI 1.43-4.68) for a neonatal diagnosis of malformations. However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups. CONCLUSION: There was a small increase in the risk of having a major malformation after exposure to AEDs in monotherapy. Exposure to VPA seems to carry a higher risk than exposure to CBZ.
K Wide; B Winbladh; B Källén
Related Documents :
16113149 - Eurocat: 25 years of european surveillance of congenital anomalies.
1141279 - Infantile idiopathic scoliosis. causative factors, particularly in the first six months...
20956899 - Congenital muscular torticollis: experience of 14 cases.
20337219 - Effect of pathoanatomic diagnosis on the quality of birth defects surveillance in china.
2817779 - "pure" partial trisomy 3p due to the malsegregation of a balanced maternal translocatio...
2235759 - Fatal malformations in jamaica.
3976759 - Diabetes in pregnancy: a population-based study of incidence, referral for care, and pe...
8837129 - Retinopathy of prematurity.
6257149 - Assessment of neuromuscular function in infants.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  93     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  174-6     Citation Subset:  IM    
Department of Clinical Sciences, Division of Pediatrics, Karolinska Insitutet, Huddinge University Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Multiple / chemically induced*,  diagnosis*,  epidemiology
Anticonvulsants / adverse effects*
Carbamazepine / adverse effects*
Epilepsy / drug therapy*
Fetal Diseases / chemically induced*
Infant, Newborn
Population Surveillance
Pregnancy Complications
Pregnancy Outcome
Prenatal Exposure Delayed Effects*
Valproic Acid / adverse effects*
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum procalcitonin and C-reactive protein in children with diarrhoea of various aetiologies.
Next Document:  Changing incidence and outcome of infants with respiratory distress syndrome in the 1990s: a populat...