Document Detail

Major inter-laboratory variations in PSA testing practices: results from national surveys in Ireland in 2006 and 2007.
MedLine Citation:
PMID:  18841439     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ireland had the highest prostate cancer incidence in Europe in 2006. In that year, the National Cancer Forum (NCF) recommended against prostate specific antigen (PSA) testing for population-based screening. AIMS: To investigate (1) PSA services and (2) impact of the NCF recommendation. METHODS: Questionnaires were dispatched to biochemistry laboratories nationwide in 2006 and 2007. RESULTS: All 55 laboratories responded in 2006; 33/36 (89%) responded in 2007. 36 laboratories measured total PSA (tPSA); 14 measured free PSA (fPSA). Laboratories with higher tPSA workload were more likely to measure fPSA (P = 0.024). A total of 15 laboratories used age-specific PSA ranges. In 2006, there were [382,000 tPSA and [48,000 fPSA tests costing an estimated euro 4,900,000. During 2006-2007 tPSA tests increased by 11%; fPSA tests decreased by 36%. CONCLUSIONS: There is considerable inter-laboratory variation in PSA testing practices. Because of the potential clinical consequences, standardisation should be considered. Testing practice was unaffected by the NCF recommendation.
F J Drummond; L Sharp; H Comber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-08
Journal Detail:
Title:  Irish journal of medical science     Volume:  177     ISSN:  1863-4362     ISO Abbreviation:  Ir J Med Sci     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-03-10     Revised Date:  2009-05-21    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
National Cancer Registry Ireland, Building 6800, Airport Business Park, Kinsale Rd., Cork, Ireland.
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MeSH Terms
Data Collection
Laboratory Techniques and Procedures / standards*
Mass Screening*
Middle Aged
Physicians, Family / statistics & numerical data
Prostate-Specific Antigen / analysis*
Prostatic Neoplasms / diagnosis*,  pathology
Urology / statistics & numerical data
Workload / statistics & numerical data
Reg. No./Substance:
EC Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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