Document Detail

Major increase in brain natriuretic peptide indicates right ventricular systolic dysfunction in patients with heart failure.
MedLine Citation:
PMID:  12921809     Owner:  NLM     Status:  MEDLINE    
This study sought to investigate whether the presence of right ventricular systolic dysfunction with pre-existing left ventricular systolic dysfunction is associated with higher plasma brain natriuretic peptide (BNP) levels, compared with patients with isolated left ventricular dysfunction. Eighty-five patients referred for evaluation of isotopic ventricular function were prospectively included in the study. Left (LVEF) and right (RVEF) ventricular ejection fractions were evaluated by gated blood pool scintigraphy and compared with plasma BNP levels. BNP correlated negatively with LVEF, except in patients with ischaemic heart disease (P=0.09) and in patients with LVEF<40% (P=0.11). In contrast, BNP levels correlated negatively with RVEF for all subgroups. Among patients with RVEF<40%, no significant BNP difference was found between patients with or without additional left ventricular systolic dysfunction (P=0.51). Among patients with LVEF<40%, plasma BNP levels were significantly higher in patients with RVEF<40% than in patients with RVEF>/=40% (P=0.004) whereas age, renal function, clinical findings, ventricular volumes, LVEF or medication were not significantly different. In conclusion, an important increase in BNP levels in patients with left ventricular systolic dysfunction should be considered by cardiologists as an indication of high risk of right ventricular dysfunction and should justify further investigation.
Denis Mariano-Goulart; Marie-Claude Eberlé; Vincent Boudousq; Azadeh Hejazi-Moughari; Christophe Piot; Charles Caderas de Kerleau; Régis Verdier; Marie-Luce Barge; Frédéric Comte; Nicole Bressot; Michel Rossi; Pierre-Olivier Kotzki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  5     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2003-12-23     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  481-8     Citation Subset:  IM    
Department of Nuclear Medicine, Montpellier University Hospital, 371, Avenue du Doyen Gaston Giraud, 34295 Cedex 5, Montpellier, France.
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MeSH Terms
Aged, 80 and over
Gated Blood-Pool Imaging
Heart Failure / blood,  physiopathology*
Middle Aged
Natriuretic Peptide, Brain / blood*
ROC Curve
Sensitivity and Specificity
Ventricular Dysfunction, Left / blood,  physiopathology
Ventricular Dysfunction, Right / blood,  physiopathology*
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

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