| Major histocompatibility complex (MHC)-mediated immune regulation of decidual leukocytes at the fetal-maternal interface. | |
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MedLine Citation:
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PMID: 20347157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Self and non-self recognition is the key mechanism by which the immune system determines whether or not to mount an immune response. During pregnancy the maternal immune system must tolerate the persistence of non-self semi-allogeneic fetal cells in the maternal tissue. Although many mechanisms have been shown to contribute to the prevention of a destructive maternal immune response to fetal cells, the immune acceptance of the allogeneic fetus in pregnancy largely remains an immunological paradox (Billingham et al., 1953). The aim of this review is to describe the expression of the polymorphic histocompatibility antigens at the fetal-maternal interface, their interaction with maternal leukocytes and their possible roles in immune regulation at the fetal-maternal interface during human pregnancy. |
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Authors:
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Tamara Tilburgs; Sicco A Scherjon; Frans H J Claas |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-29 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 85 ISSN: 1872-7603 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 58-62 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Decidua
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immunology* Female Humans Leukocytes / immunology* Major Histocompatibility Complex / immunology* Maternal-Fetal Exchange / immunology* Pregnancy / immunology* |
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