Document Detail


Major differences in the pulmonary circulation between birds and mammals.
MedLine Citation:
PMID:  17222589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lungs of domestic chickens were perfused with blood or dextran/saline and the pulmonary artery pressure (P(a)) and venous pressure (P(v)) were varied in relation to air capillary pressure (P(A)). In Zone 3 conditions, pulmonary vascular resistance (PVR) was virtually unchanged with increases in either P(a) or P(v). This is very different behavior from mammals where the same interventions greatly reduce PVR. In Zone 2 conditions blood flow was essentially independent of P(v) as in mammalian lungs but all the capillaries appeared to be open, apparently incompatible with a Starling resistor mechanism. In Zone 1 the capillaries were open even when P(A) exceeded P(a) by over 30 cm H(2)O which is very different behavior from that of the mammalian lung. We conclude that the air capillaries that surround the blood capillaries provide rigid support in both compression and expansion of the vessels. The work suggests a pathogenesis for pulmonary hypertension syndrome in chickens which costs the broiler industry $1 billion per year.
Authors:
John B West; Rebecca R Watson; Zhenxing Fu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-12-19
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  157     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-02     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  382-90     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA. jwest@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Capillary Resistance / physiology
Chickens / anatomy & histology,  physiology*
Dogs / anatomy & histology,  physiology*
Lung / anatomy & histology,  physiology
Lung Volume Measurements / methods
Pulmonary Circulation / physiology*
Respiration*
Grant Support
ID/Acronym/Agency:
R01 HL 60968/HL/NHLBI NIH HHS; R01 HL060968-06/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Respir Physiol Neurobiol. 2007 Aug 1;157(2-3):391-2   [PMID:  17412654 ]
Respir Physiol Neurobiol. 2007 Nov 15;159(2):141-5; author reply 146   [PMID:  17900998 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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