Document Detail

Major depressive disorder and white matter abnormalities: a diffusion tensor imaging study with tract-based spatial statistics.
MedLine Citation:
PMID:  19467559     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A few diffusion tensor imaging (DTI) studies have shown abnormalities in areas of white matter tracts involved in mood regulation in geriatric depressive patients, using a region-of-interest technique. A voxel-based morphometry DTI study of young depressive patients reported similar results. In this study, we explored the structure of the white matter of the whole brain with DTI in middle-aged major depressive disorder (MDD) patients, using novel tract-based spatial statistics. METHODS: Sixteen MDD patients and 20 controls underwent DTI. An automated tract-based spatial method (TBSS) was used to analyze the scans. RESULTS: Compared with controls, the MDD patients showed a trend for lower values of fractional anisotropy (FA) in the left sagittal stratum, and suggestive decreased FA in the right cingulate cortex and posterior body of corpus callosum. Regressing out the duration and severity of disorder in the model did not change the finding in the sagittal stratum, but dissipated the decrease of FA in latter regions. LIMITATIONS: Possibly by reason of a relatively small study sample for a TBSS, the results are suggestive, and should be replicated in further studies. CONCLUSIONS: A novel observer-independent DTI method showed decreased FA in the middle-aged MDD patients in white matter regions that have previously connected to the emotional regulation. Lower FA might imply underlying structural abnormalities that contribute to the dysfunction detected in the limbic-cortical network of depressive patients.
Tuula Kiesepp?; Mervi Eerola; Riitta M?ntyl?; Tuomas Neuvonen; Veli-Pekka Poutanen; Katariina Luoma; Annamari Tuulio-Henriksson; Pekka Jylh?; Outi Mantere; Tarja Melartin; Heikki Ryts?l?; Maria Vuorilehto; Erkki Isomets?
Related Documents :
20881589 - Relationship between transcranial magnetic stimulation and percutaneous electrical stim...
19010859 - [18f]fluorothymidine positron emission tomography before and 7 days after gefitinib tre...
11448369 - Brain blood flow changes in depressed patients treated with interpersonal psychotherapy...
21822149 - Psychosocial functioning and health related quality of life in paediatric inflammatory ...
22228379 - Relationship of endothelial function and atherosclerosis to treatment response in late-...
22741619 - A human laboratory study investigating the effects of quetiapine on marijuana withdrawa...
6881019 - Clinical significance of slow paroxysmal atrial tachycardia.
7563559 - High-dose nicotine patch therapy. percentage of replacement and smoking cessation.
17350489 - Prescription rheumatology practices among mexican specialists.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of affective disorders     Volume:  120     ISSN:  1573-2517     ISO Abbreviation:  J Affect Disord     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  IM    
Department of Mental Health and Alcohol Research, National Public Heath Institute, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / anatomy & histology*,  physiopathology*
Corpus Callosum / anatomy & histology,  physiopathology
Depressive Disorder, Major / epidemiology*,  physiopathology*
Diagnostic and Statistical Manual of Mental Disorders
Diffusion Tensor Imaging*
Functional Laterality / physiology
Gyrus Cinguli / anatomy & histology,  physiopathology
Limbic System / anatomy & histology,  physiopathology
Nerve Net / anatomy & histology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nutrient characteristics in the Yangtze River Estuary and the adjacent East China Sea before and aft...
Next Document:  A 12 months follow-up study of depression among nursing-home patients in Norway.