Document Detail


Major congenital malformations presenting in the first 24 hours of life in 3865 consecutive births in south of Beirut. Incidence and pattern.
MedLine Citation:
PMID:  10349259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
3865 consecutive newborns delivered between 2/1/91 and 7/31/93 were prospectively studied. All the neonates received a physical examination during the first 24 hours of life. Major congenital anomalies (MCA) were found in 64 newborns at incidence of 16.5/1000 births. 61 patients with full description included 40 with single and 21 with multiple MCA. Out of the latter 2 had syndromal (Osteogenesis Imperfecta and Achondroplasia), 16 nonsyndromal and 3 sequence multiple (Pierre Robin, diaphragmatic hernia with dextrocardia and breech presentation sequence) malformations. Skeletal anomalies were leading among the group (46.29%), followed by genitourinary (GU) defects (12.14%) and neural tube fusion defects (NTFD) (11.21%). Incidence of low birth weight (LBW) was 6% among the studied group of newborns and 26.56% among the group with MCA. Incidence of MCA among the group of LBW was 7.32%. While 65.62% of cases were amenable to surgery the malformed infants formed 24.34% of all perinatal death suggesting that improved care given to these patients will appreciably participate in reducing perinatal mortality. Incidence of NTFD (3.10/1000 births) was higher than in many western and middle eastern reports suggesting the need for further testing for incidence and etiology. Among the malformed infants, the rate of low birth weight and the rate of parental first cousin consanguinity were significantly higher than corresponding rates among normal infants in a control group.
Authors:
Z Bittar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Le Journal médical libanais. The Lebanese medical journal     Volume:  46     ISSN:  0023-9852     ISO Abbreviation:  J Med Liban     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-06-17     Completed Date:  1999-06-17     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  0375352     Medline TA:  J Med Liban     Country:  LEBANON    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Affiliation:
Pediatric Department, Lebanese University Medical School, Branch I & Middle East Hospital, Beirut, Lebanon.
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MeSH Terms
Descriptor/Qualifier:
Congenital Abnormalities / classification,  diagnosis*,  epidemiology*
Consanguinity
Environmental Exposure / statistics & numerical data
Humans
Incidence
Infant, Low Birth Weight
Infant, Newborn
Lebanon / epidemiology
Population Surveillance
Poverty / statistics & numerical data
Prospective Studies
Risk Factors
Urban Population*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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