Document Detail

Major birth defects among infants with Down's syndrome in Alexandria, Egypt (1995-2000).
MedLine Citation:
PMID:  12200989     Owner:  NLM     Status:  MEDLINE    
A case-control study of 514 infants with confirmed Down's syndrome (DS) was carried out during the period 1 July 1995-30 June 2000 to investigate the risk factors for the occurrence of congenital anomalies among DS cases. Our results showed that the significant risk factors for developing any type of congenital anomalies among DS were: parental consanguinity, grand-maternal consanguinity, use of antibiotics, use of oral contraceptive pills, diabetes mellitus, and maternal fever. The interaction between trisomy 21 genes and consanguinity and/or environmental factors can increase the risk of several additional birth defects.
Mohamed Mohamed Mokhtar; Moataz Abdel-Fattah
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  48     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-30     Completed Date:  2002-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-9     Citation Subset:  IM    
Department of Human Genetics, Medical Research Institute, Alexandria University, Egypt.
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MeSH Terms
Abnormalities, Multiple / diagnosis,  epidemiology*
Case-Control Studies
Cohort Studies
Confidence Intervals
Down Syndrome / diagnosis,  epidemiology*
Egypt / epidemiology
Infant, Newborn
Logistic Models
Odds Ratio
Risk Assessment
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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