Document Detail

Major basic protein as a marker of malignant potential in trophoblastic neoplasia.
MedLine Citation:
PMID:  8828426     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We tested whether serum pregnancy-associated major basic protein levels distinguish between benign and malignant trophoblastic disease. STUDY DESIGN: We compared serum pregnancy-associated major basic protein levels in seven patient groups: nonpregnant and pregnant controls, partial moles, complete moles, persistent moles, placental-site trophoblastic tumors, and choriocarcinoma. RESULTS: The results showed that patients with partial and complete moles had elevated serum pregnancy-associated major basic protein levels comparable to normal pregnancy. In contrast, patients with persistent mole, placental-site trophoblastic tumors and choriocarcinoma had low median serum levels comparable to those of the nonpregnant controls. Significant differences were shown between the complete and persistent mole groups (p = 0.0001) and between the complete mole group and the choriocarcinoma group (p = 0.0001); however, persistent moles were indistinguishable from choriocarcinoma (p = 0.2010). CONCLUSION: Serum pregnancy-associated major basic protein levels thus distinguish between benign disorders, such as pregnancy and partial and complete moles, and trophoblastic tumors, such as persistent moles and choriocarcinoma. The absence of elevated serum levels of pregnancy-associated major basic protein may be useful clinically to indicate a more aggressive or frankly malignant tumor.
K V Gurian; K C Podratz; S A Elg; L B Twiggs; J R Lurain; J M Wagner; G J Gleich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  175     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-11-04     Completed Date:  1996-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  632-7     Citation Subset:  AIM; IM    
Department of Obstetrics, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Blood Proteins
Choriocarcinoma / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Eosinophil Granule Proteins
Fluorescent Antibody Technique
Immunoradiometric Assay
Time Factors
Trophoblastic Neoplasms / blood*
Trophoblastic Tumor, Placental Site / blood
Tumor Markers, Biological / blood*
Uterine Neoplasms / blood
Grant Support
Reg. No./Substance:
0/Blood Proteins; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Eosinophil Granule Proteins; 0/Tumor Markers, Biological; EC 3.1.-/Ribonucleases

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