Document Detail


Major adverse cardiac and cerebrovascular events after the Ross procedure: a report from the German-Dutch Ross Registry.
MedLine Citation:
PMID:  20837916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of the study is to report major cardiac and cerebrovascular events after the Ross procedure in the large adult and pediatric population of the German-Dutch Ross registry. These data could provide an additional basis for discussions among physicians and a source of information for patients. METHODS AND RESULTS: One thousand six hundred twenty patients (1420 adults; 1211 male; mean age, 39.2±16.2 years) underwent a Ross procedure between 1988 and 2008. Follow-up was performed on an annual basis (median, 6.2 years; 10 747 patient-years). Early and late mortality were 1.2% (n=19) and 3.6% (n=58; 0.54%/patient-year), respectively. Ninety-three patients underwent 99 reinterventions on the autograft (0.92%/patient-year); 78 reinterventions in 63 patients on the pulmonary conduit were performed (0.73%/patient-year). Freedom from autograft or pulmonary conduit reoperation was 98.2%, 95.1%, and 89% at 1, 5, and 10 years, respectively. Preoperative aortic regurgitation and the root replacement technique without surgical autograft reinforcement were associated with a greater hazard for autograft reoperation. Major internal or external bleeding occurred in 17 (0.15%/patient-year), and a total of 38 patients had composite end point of thrombosis, embolism, or bleeding (0.35%/patient-year). Late endocarditis with medical (n=16) or surgical treatment (n=29) was observed in 38 patients (0.38%/patient-year). Freedom from any valve-related event was 94.9% at 1 year, 90.7% at 5 years, and 82.5% at 10 years. CONCLUSIONS: Although longer follow-up of patients who undergo Ross operation is needed, the present series confirms that the autograft procedure is a valid option to treat aortic valve disease in selected patients. The nonreinforced full root technique and preoperative aortic regurgitation are predictors for autograft failure and warrant further consideration. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00708409.
Authors:
Hans-H Sievers; Ulrich Stierle; Efstratios I Charitos; Thorsten Hanke; Martin Misfeld; J F Matthias Bechtel; Armin Gorski; Ulrich F W Franke; Bernhard Graf; Derek R Robinson; Ad J J C Bogers; Ali Dodge-Khatami; Juergen O Boehm; Joachim G Rein; Cornelius A Botha; Ruediger Lange; Juergen Hoerer; Anton Moritz; Thorsten Wahlers; Martin Breuer; Katharina Ferrari-Kuehne; Roland Hetzer; Michael Huebler; Gerhard Ziemer; Johanna J M Takkenberg; Wolfgang Hemmer;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Circulation     Volume:  122     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S216-23     Citation Subset:  AIM; IM    
Affiliation:
University of Luebeck, Department of Cardiac and Thoracic Vascular Surgery, Luebeck, Germany.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00708409
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MeSH Terms
Descriptor/Qualifier:
Adult
Aortic Valve / surgery*
Aortic Valve Insufficiency / mortality*,  surgery*
Endocarditis / etiology,  mortality
Female
Follow-Up Studies
Germany
Hemorrhage / etiology,  mortality
Humans
Male
Middle Aged
Netherlands
Postoperative Complications / mortality*,  surgery
Registries*
Transplantation, Autologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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