Document Detail


Major advances associated with the biosynthesis of milk.
MedLine Citation:
PMID:  16537956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammary gland has an incredible level of organization and a remarkable ability to convert circulating nutrients into milk components. This review highlights four areas of high interest in the biology of milk synthesis where advances over the last quarter-century have resulted in new understanding or revealed new opportunities. First, advances in our understanding of the mechanisms of milk secretion has led to a substantial increase in our knowledge of the intracellular origin of lipid droplets and the identity and potential function of milk fat globule membrane proteins in milk-lipid secretion. Second, recent breakthroughs have advanced our understanding of the nutritional regulation of milk fat and highlighted the interrelations between dietary components, digestive processes in the rumen, and the regulation of mammary synthesis of milk fat. Third, nutritional quality is becoming increasingly important in food choices because of consumer awareness of the links between diet and health. The traditional nutritional value of milk and dairy products is well established, but recent discoveries have identified a number of "bioactive" components in milk with potential to improve human health. Finally, the concept of genetic engineering and the use of animals as "bioreactors" and the "pharming" of proteins not normally found in milk have gained recognition, with the dairy industry ideally suited to take advantage of advances in these areas.
Authors:
D E Bauman; I H Mather; R J Wall; A L Lock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of dairy science     Volume:  89     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-15     Completed Date:  2006-05-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1235-43     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Cornell University, Ithaca, NY 14853, USA. deb6@cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena
Animals
Dairy Products
Dairying / trends
Fats / analysis
Female
Genetic Engineering
Glycolipids / physiology
Glycoproteins / physiology
Humans
Lactation
Linoleic Acids, Conjugated
Mammary Glands, Animal / physiology
Milk / chemistry,  physiology*,  secretion
Milk Proteins / biosynthesis
Chemical
Reg. No./Substance:
0/Fats; 0/Glycolipids; 0/Glycoproteins; 0/Linoleic Acids, Conjugated; 0/Milk Proteins; 0/milk fat globule

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