| The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 19654554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253 A>G) and tumor necrosis factor (TNF -308A, rs1800629 G>A), form the G-A haplotype repeatedly associated with increased risk of non-Hodgkin lymphoma (NHL) in individuals uninfected with HIV-1. This association has been observed alone or in combination with human leukocyte antigens HLA-B*08 or HLA-DRB1*03 in the major histocompatibility complex (MHC). Which gene variant on this highly conserved extended haplotype (CEH 8.1) in whites most likely represents a true etiologic factor remains uncertain. OBJECTIVE: We aimed to determine whether the reported association of the G-A haplotype of LTA-TNF with non-AIDS NHL also occurs with AIDS-related NHL. METHODS: SNPs in LTA and TNF and in 6 other genes nearby were typed in 140 non-Hispanic European American pairs of AIDS-NHL cases and matched controls selected from HIV-infected men in the Multicenter AIDS Cohort Study. RESULTS: The G-A haplotype and a 4-SNP haplotype in the neighboring gene cluster (rs537160 (A) rs1270942 (G), rs2072633 (A), and rs6467 (C)) were associated with AIDS-NHL (odds ratio = 2.7, 95% confidence interval: 1.5 to 4.8, P = 0.0009; and odds ratio = 3.2, 95% confidence interval: 1.6 to 6.6, P = 0.0008; respectively). These 2 haplotypes occur in strong linkage disequilibrium with each other on CEH 8.1. CONCLUSION: The CEH 8.1-specific haplotype association of MHC class III variants with AIDS-NHL closely resembles that observed for non-AIDS NHL. Corroboration of an MHC determinant of AIDS and non-AIDS NHL alike would imply an important pathogenetic mechanism common to both. |
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Authors:
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Brahim Aissani; Kisani M Ogwaro; Sadeep Shrestha; Jianming Tang; Elizabeth C Breen; Hui-Lee Wong; Lisa P Jacobson; Charles S Rabkin; Richard F Ambinder; Otoniel Martinez-Maza; Richard A Kaslow |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 52 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-02-16 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 170-9 Citation Subset: IM; X |
Affiliation:
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Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA. baissani@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gene Frequency Genetic Predisposition to Disease Genetic Testing HLA Antigens / genetics* Haplotypes Hispanic Americans Humans Lymphoma, AIDS-Related / genetics* Lymphoma, Non-Hodgkin / genetics* Lymphotoxin-alpha / genetics Male Polymorphism, Single Nucleotide* Tumor Necrosis Factor-alpha / genetics |
| Grant Support | |
ID/Acronym/Agency:
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5-M01-RR-00722/RR/NCRR NIH HHS; P30 AI 045008/AI/NIAID NIH HHS; P30 AI045008-01/AI/NIAID NIH HHS; P50 CA096888-01/CA/NCI NIH HHS; P50-CA96888/CA/NCI NIH HHS; R01 CA073475-03/CA/NCI NIH HHS; R01 CA106168-01A1/CA/NCI NIH HHS; R01-CA106168/CA/NCI NIH HHS; R01-CA73475/CA/NCI NIH HHS; UO1-AI-35039/AI/NIAID NIH HHS; UO1-AI-35040,/AI/NIAID NIH HHS; UO1-AI-35041/AI/NIAID NIH HHS; UO1-AI-35042/AI/NIAID NIH HHS; UO1-AI-35043/AI/NIAID NIH HHS; UO1-AI-37613/AI/NIAID NIH HHS; UO1-AI-37984/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Lymphotoxin-alpha; 0/Tumor Necrosis Factor-alpha |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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