| Majewski osteodysplastic primordial dwarfism type II (MOPD II): natural history and clinical findings. | |
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MedLine Citation:
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PMID: 15368497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A description of the clinical features of Majewski osteodysplastic primordial dwarfism type II (MOPD II) is presented based on 58 affected individuals (27 from the literature and 31 previously unreported cases). The remarkable features of MOPD II are: severe intrauterine growth retardation (IUGR), severe postnatal growth retardation; relatively proportionate head size at birth which progresses to true and disproportionate microcephaly; progressive disproportion of the short stature secondary to shortening of the distal and middle segments of the limbs; a progressive bony dysplasia with metaphyseal changes in the limbs; epiphyseal delay; progressive loose-jointedness with occasional dislocation or subluxation of the knees, radial heads, and hips; unusual facial features including a prominent nose, eyes which appear prominent in infancy and early childhood, ears which are proportionate, mildly dysplastic and usually missing the lobule; a high squeaky voice; abnormally, small, and often dysplastic or missing dentition; a pleasant, outgoing, sociable personality; and autosomal recessive inheritance. Far-sightedness, scoliosis, unusual pigmentation, and truncal obesity often develop with time. Some individuals seem to have increased susceptibility to infections. A number of affected individuals have developed dilation of the CNS arteries variously described as aneurysms and Moya Moya disease. These vascular changes can be life threatening, even in early years because of rupture, CNS hemorrhage, and strokes. There is variability between affected individuals even within the same family. |
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Authors:
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Judith G Hall; Christina Flora; Charles I Scott; Richard M Pauli; Kimi I Tanaka |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: American journal of medical genetics. Part A Volume: 130A ISSN: 1552-4825 ISO Abbreviation: Am. J. Med. Genet. A Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-15 Completed Date: 2004-11-19 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: United States |
Other Details:
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Languages: eng Pagination: 55-72 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Department of Medical Genetics, UBC and Children's and Women's Health Centre of British Columbia Vancouver, British Columbia, Canada. jhall@cw.bc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple* Adolescent Bone Diseases, Developmental / complications, etiology*, pathology Cerebral Arterial Diseases / complications, etiology* Child Child Development Child, Preschool Craniofacial Abnormalities / etiology*, pathology Dwarfism / etiology*, pathology Female Fetal Growth Retardation* Head / abnormalities Humans Infant Infant, Newborn Male Personality Puberty Short Rib-Polydactyly Syndrome / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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