Document Detail


Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats.
MedLine Citation:
PMID:  20567593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We assessed the ability of two commercially-available fractions labeled SX and D derived from the edible maitake mushroom to overcome many age-associated metabolic perturbations such as progressive, age-related elevation of blood pressure, over activity of the renin-angiotensin system (RAS), decreased insulin sensitivity, and inflammation in an in vivo laboratory model.
DESIGN AND METHOD: We divided forty mature, female Sprague-Dawley rats (SD) into five groups of eight. SD ingested regular rat chow containing added sucrose (20% w/w). The groups received baseline diet alone (control) or baseline diet containing captopril, niacin-bound chromium, maitake fraction SX, or maitake fraction D. In addition to blood pressure readings, the following procedures were implemented: losartan and insulin challenges, evaluation of serum ACE activity, glucose tolerance testing, blood chemistries, LNAME challenge, and measurement of various circulating cytokines.
RESULTS: We found that implementation of all test conditions stopped the gradual elevation of systolic blood pressure (SBP) in the SD over the four months of study, even reversing some of the previous elevation that occurred over time. In general, the treatment groups showed decreased activity of the RAS estimated by less lowering of SBP after losartan challenge and decreased serum ACE activity and were more sensitive to exogenous insulin challenge. TNFa levels decreased in all four test groups suggesting a lessening of the inflammatory state.
CONCLUSIONS: We believe our data suggest that maitake mushroom fractions lessen age-related hypertension, at least in part, via effects on the RAS; enhance insulin sensitivity; and reduce some aspects of inflammation--actions that should lead to a longer, healthier life span.
Authors:
Harry G Preuss; Bobby Echard; Debasis Bagchi; Nicholas V Perricone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-07
Journal Detail:
Title:  International journal of medical sciences     Volume:  7     ISSN:  1449-1907     ISO Abbreviation:  Int J Med Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-09-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101213954     Medline TA:  Int J Med Sci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  169-80     Citation Subset:  IM    
Affiliation:
Georgetown University Medical Center, Department of Physiology, Washington, DC 20057, USA. preusshg@georgetown.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Antihypertensive Agents / chemistry,  pharmacokinetics*,  therapeutic use
Blood Pressure / drug effects*
Body Weight / drug effects
Eating / drug effects
Female
Glucose Tolerance Test
Grifola / chemistry*
Hypertension* / drug therapy
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Antihypertensive Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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