Document Detail


Maintenance of wakefulness test as a predictor of driving performance in patients with untreated obstructive sleep apnea.
MedLine Citation:
PMID:  17425229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVE: To determine the ability of Maintenance of Wakefulness Test (MWT) to predict simulated driving performance in patients suffering from sleep apnea syndrome.
DESIGN: Study involving one hour of simulated driving, one night of polysomnography (PSG), and a 4 x 40-minute MWT.
SETTING: Sleep laboratory.
PATIENTS: Thirty male patients with untreated obstructive sleep apnea syndrome (OSAS) (mean age [+/- SD] = 51 +/- 8 years, range 34-62; mean body mass index (BMI) [+/- SD] = 29 +/- 3, range 24-37; mean apnea/hypopnea index (AHI) [+/- SD] = 43 +/- 24, range 14-96). As defined by MWT mean sleep latency, 23.3% of the patients were sleepy (0-19 min), 33.3% were alert (20-33 min), and 43.4% were fully alert (34-40 min).
MEASUREMENTS: Nocturnal PSG, mean sleep latency at 4 x 40-minute MWT trials, Epworth Sleepiness Scale (ESS), and standard deviation from the center of the road (SDS) on driving simulator.
RESULTS: Mean MWT scores inversely correlated with SDS during the simulated driving session (Pearson's r = -0.513, P < 0.01). We found a significant effect of MWT groups (sleepy, alert, or fully alert) on SDS (ANOVA, F(2, 29) = 5.861, P < 0.01). Post hoc tests revealed that the sleepy group had a higher SDS than the fully alert group (P = 0.006). ESS, AHI, microarousal index, and total sleep time did not predict simulated driving performance.
CONCLUSIONS: A pathological MWT mean sleep latency (0-19 min) is associated with simulated driving impairment. Before MWT can be used to predict the driving ability of untreated patients with OSAS, further studies are needed to confirm that pathological MWT scores are associated with real driving impairment.
Authors:
Patricia Sagaspe; Jacques Taillard; Guillaume Chaumet; Christian Guilleminault; Olivier Coste; Nicholas Moore; Bernard Bioulac; Pierre Philip
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sleep     Volume:  30     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-06-08     Revised Date:  2011-05-17    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Affiliation:
Clinique du Sommeil, CHU Pellegrin, Bordeaux, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal
Automobile Driving*
Body Mass Index
Computer Simulation
Disorders of Excessive Somnolence / diagnosis
Female
Humans
Male
Middle Aged
Polysomnography
Reaction Time
Sleep
Sleep Apnea, Obstructive / diagnosis*
Wakefulness*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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