Document Detail

Maintenance treatment in the prevention of gastric ulcer recurrence: results of a 3-year multicenter study.
MedLine Citation:
PMID:  10163331     Owner:  NLM     Status:  MEDLINE    
This study reports data from the third year of a multicenter, prospective, open, 3-year trial in which 290 patients with gastric ulcer followed different treatment protocols (ranitidine or sucralfate or no drug) during the first 2 years. One hundred forty-two patients completed the first 2 years; 50 of them completed the third-year investigation. All 50 patients were left untreated and underwent clinical tests every 3 months and endoscopic checkups every 6 months and for every painful episode lasting more than 3 days. During year 3 follow-up, 1 patient dropped out and 2 had relapses. Mean consumption of antacids ranged from zero to three tablets per week. No gastric neoplasms were detected during the third year of follow-up. These findings suggest that no treatment may be needed in the long-term management of patients with gastric ulcer. No malignancies were found during the second and third years of follow-up, suggesting that close endoscopic examination is necessary only for 6 months after the acute lesion has healed. Maintenance therapy with antisecretory or cytoprotective drugs may be advisable for 1 year.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Advances in therapy     Volume:  12     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-10-25     Completed Date:  1996-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  T    
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MeSH Terms
Anti-Ulcer Agents / therapeutic use*
Long-Term Care
Middle Aged
Prospective Studies
Ranitidine / therapeutic use*
Stomach Ulcer / drug therapy*,  pathology
Sucralfate / therapeutic use*
Reg. No./Substance:
0/Anti-Ulcer Agents; 54182-58-0/Sucralfate; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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