| Maintenance of normouricaemia during adolescence in sickle-cell anaemia. | |
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MedLine Citation:
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PMID: 1527818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aspects of uric acid metabolism were investigated during adolescence in 122 patients with sickle-cell anaemia in the steady state and 52 matched controls with normal haemoglobin AA. Plasma urate concentrations were significantly lower (P less than 0.02) in male patients than in male controls. No significant differences were observed between either female patients and female controls or total patient group and total control group. Further study in subgroups of the subjects showed that all indices of urinary urate excretion in male patients were significantly increased over male controls or female patients. The increases in these indices in female patients over female controls were not statistically significant. Significant inverse correlations were also found between plasma urate and either renal urate clearance (r = -0.483, P less than 0.02) or fractional urate excretion (r = -0.398, P less than 0.05) in the patients. These findings indicate that patients with sickle-cell anaemia maintain normouricaemia during adolescence by increasing renal urate disposal. This process appears to be more efficient in the male patients. |
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Authors:
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A O Olukoga; H O Adewoye; R T Erasmus; M A Adedoyin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 38 ISSN: 0142-6338 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-10-22 Completed Date: 1992-10-22 Revised Date: 2006-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 199-201 Citation Subset: IM |
Affiliation:
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Department of Chemical Pathology and Immunology, University of Ilorin, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Anemia, Sickle Cell / metabolism, urine* Child Female Humans Male Sex Factors Uric Acid / urine* |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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