Document Detail


Maintenance of the musculoskeletal mass by control of protein turnover: the concept of anabolic resistance and its relevance to the transplant recipient.
MedLine Citation:
PMID:  17037086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the overall size of the musculoskeletal mass is constrained by genetic limitations, both the day to day maintenance and muscle wasting and rehabilitation are regulated by protein synthesis (particularly the initiation and elongation stages of translation) and by protein breakdown. These are directly influenced by the nutritional state (size and composition of meals) and type, mode and duration of exercise. In the context of food-related changes, recent work has demonstrated that human muscle protein synthesis is almost entirely controlled by the availability of essential amino acids and protein breakdown by availability of insulin. Muscle protein synthesis is also markedly stimulated by preceding exercise in a manner independent of but additive to any effect of food. The sensing and signalling pathways within muscle are activated by food and exercise in normal healthy subjects to elevate net muscle balance for many hours after strenuous exercise. In many circumstances such as immobilisation, ageing and many chronic diseases of the lung, kidney, heart, etc (such as those often suffered by pre-transplant patients), the general debilitation includes muscle wasting. In these subjects there appears to be a general failure to respond adequately to food--so called "anabolic resistance". It seems highly likely that this circumstance will also apply to transplant recipients. It is also likely that anabolic resistance can be, to some extent, reversed by regular physical activity which may "tune up" the anabolic pathways to act in a more normal fashion. Nevertheless, the extent of re-growth and adaptation of composition of muscle in transplant patients could be hindered by drug treatment including the use of rapamycin (sirolimus) cyclosporine and corticosteroids. These predictions should be tested by examining longitudinal effects of different modes of exercise and nutritional regimens on rehabilitation of muscle in transplant patients.
Authors:
Michael J Rennie; Emilie A Wilkes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  10     ISSN:  1425-9524     ISO Abbreviation:  Ann. Transplant.     Publication Date:  2005  
Date Detail:
Created Date:  2006-10-12     Completed Date:  2006-11-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Affiliation:
School of Biomedical Sciences, University of Nottingham Graduate Entry Medical School, Derby City General Hospital. michael.rennie@nottingham.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Collagen / metabolism
Exercise / physiology*
Feeding Methods
Humans
Muscle Proteins / metabolism*
Muscle, Skeletal / metabolism*
Muscular Atrophy / prevention & control*
Nutritional Physiological Phenomena*
Organ Transplantation / rehabilitation*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Muscle Proteins; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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