| Maintenance of hepatic bile acid secretion rate during overnight fasting by bedtime bile acid administration. | |
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MedLine Citation:
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PMID: 3410216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have tested the hypothesis that the greater clinical efficacy of bedtime administration of bile acid in gallstone dissolution is due to prevention of the reduction in hepatic bile acid secretion that normally accompanies overnight interruption of the enterohepatic circulation, thus also reducing the secretion of supersaturated hepatic bile. We measured the hepatic bile acid secretion rate by combining duodenal perfusion of a nonabsorbable recovery marker (polyethylene glycol) with continuous intravenous infusion of a hepatic bile marker (indocyanine green). We studied 6 subjects with gallstones before and during administration of ursodeoxycholic acid (UDCA, 675 mg) at bedtime. Duplicate pretreatment studies revealed good reproducibility. Mean values for hepatic bile acid secretion rate were uninfluenced by chronic UDCA administration before the acute bedtime dose, but during the 4-h period after acute administration of UDCA the total bile acids secreted increased by a mean value of 2.2 mmol (p less than 0.01). Before treatment, nine of the 78 hourly samples were secreted at a hepatic bile acid secretion rate of less than 5 mumol/kg.h in the 6 patients studied, compared with only one hourly sample during UDCA administration. Super-saturated hepatic bile was secreted for a mean of 9.5 h before treatment, and for 1.2 h during UDCA treatment (p less than 0.005). We conclude that if UDCA is administered at bedtime, this maintains the hepatic bile acid secretion rate overnight, thus reducing secretion of supersaturated hepatic bile, in addition to the well-established effect of UDCA on cholesterol secretion. |
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Authors:
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A Lanzini; D Facchinetti; T C Northfield |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 95 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-10-07 Completed Date: 1988-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1029-35 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine 2, St. George's Hospital Medical School, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bile / analysis, metabolism* Chenodeoxycholic Acid / administration & dosage* Cholesterol / analysis Circadian Rhythm Deoxycholic Acid / analogs & derivatives* Eating Fasting Female Humans Liver / metabolism* Male Middle Aged Time Factors Ursodeoxycholic Acid / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 57-88-5/Cholesterol; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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