Document Detail

Maintenance of genomic integrity in mammalian kidney cells exposed to hyperosmotic stress.
MedLine Citation:
PMID:  11913455     Owner:  NLM     Status:  MEDLINE    
Changes in environmental salinity/osmolality impose an osmotic stress upon cells because, if left uncompensated, such changes will alter the conserved intracellular ionic milieu and macromolecular density, for which cell metabolism in most extant cells has been optimized. Cell responses to osmotic stress include rapid posttranslational and slower transcriptional events for the compensatory regulation of cell volume, intracellular electrolyte concentrations, and protein stability/activity. Changes in external osmolality are perceived by osmosensors that control the activation of signal transduction pathways giving rise to the above responses. We have recently shown that the targets of such pathways include cell cycle-regulatory and DNA damage-inducible genes (reviewed in Kültz, D., 2000. Environmental stressors and gene responses, Elsevier, Amsterdam. pp 157-179). Moreover, recent evidence suggests that hyperosmotic stress causes chromosomal aberrations and DNA double-strand breaks in mammalian cells. We propose that the modulation of cell cycle checkpoints and the preservation of genomic integrity are important aspects of cellular osmoprotection and as essential for cellular osmotic stress resistance as the capacity for cell volume regulation and maintaining inorganic ion homeostasis and protein stability/activity.
D Kültz; D Chakravarty
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  130     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-04-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-8     Citation Subset:  IM    
The Whitney Laboratory, University of Florida, St Augustine 32080, USA.
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MeSH Terms
Cell Cycle
DNA Repair
DNA Replication
Kidney / cytology,  metabolism*
Osmotic Pressure*
Signal Transduction
Transcription, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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