Document Detail

Maintenance-dose prediction based on a single determination of concentration: general applicability to two-compartment drugs with reference to lithium.
MedLine Citation:
PMID:  6644587     Owner:  NLM     Status:  MEDLINE    
A general approach to the selection of the maintenance dose (Dm) required to give a desired steady-state concentration of drug based on a single determination of concentration after a test dose (C*) is extended to drugs with two-compartment pharmacokinetic characteristics. Using the equation developed, the value of the proportionality factor relating 1/Dm to C was found to be within 3.2% of the value calculated from a published nomogram for lithium. The inherent error is shown to be a function of the value of the hybrid rate constants alpha and beta, as well as the value of an intercompartmental transfer rate constant, k21, in an individual.
C L Zimmerman; J T Slattery
Related Documents :
23771157 - Integration of biosensors and drug delivery technologies for early detection and chroni...
24394497 - Common bile duct dilatation in drug users with chronic hepatitis c is associated with c...
21269267 - Mitochondrial tolerance to drugs and toxic agents in ageing and disease.
22927497 - In vitro antileishmanial drug susceptibility of clinical isolates from patients with in...
10511057 - Failure of erythromycin breath test to correlate with midazolam clearance as a probe of...
19621007 - A holy grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmaco...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  72     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1262-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Lithium / administration & dosage*,  blood
Models, Biological
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Subnanogram quantitation of chlorpromazine in plasma by high-performance liquid chromatography with ...
Next Document:  Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymel...