Document Detail


Maintenance-dose prediction based on a single determination of concentration: general applicability to two-compartment drugs with reference to lithium.
MedLine Citation:
PMID:  6644587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A general approach to the selection of the maintenance dose (Dm) required to give a desired steady-state concentration of drug based on a single determination of concentration after a test dose (C*) is extended to drugs with two-compartment pharmacokinetic characteristics. Using the equation developed, the value of the proportionality factor relating 1/Dm to C was found to be within 3.2% of the value calculated from a published nomogram for lithium. The inherent error is shown to be a function of the value of the hybrid rate constants alpha and beta, as well as the value of an intercompartmental transfer rate constant, k21, in an individual.
Authors:
C L Zimmerman; J T Slattery
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  72     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1262-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Humans
Lithium / administration & dosage*,  blood
Models, Biological
Time Factors
Chemical
Reg. No./Substance:
7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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