Document Detail


Maintenance of clinical remission in ANCA-associated vasculitis.
MedLine Citation:
PMID:  23147895     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A fundamental change in management of antineutrophil cytoplasmic antibody-associated vasculitis in the past 10 years is the early focussed use of aggressive immunosuppression, using regimens comprised of widely available medications. Using a clinical framework to quantify morbidity, we can induce remission in most patients within 3-6 months using glucocorticoids plus methotrexate, cyclophosphamide or rituximab, with additional plasmapheresis when indicated. Difficulty in maintaining remission probably relates to the difference between true pathophysiological remission and the absence of clinical, serological or radiological evidence of disease activity. For surviving patients, the cumulative problems of relapse, burden of disease, or its treatment are coupled with pre-existing diseases or new conditions arising since diagnosis. Initial early control should reduce subsequent damage, but what effect it will have on relapse is not clear. In the absence of a cure, future trials should focus on reducing toxicity and comorbidity as well as controlling disease.
Authors:
Raashid Luqmani
Related Documents :
6699715 - Granulomolecular hypertrophy of the cerebellum (lhermitte-duclos disease). case report.
8362585 - Cytodiagnosis of coats' disease from an ocular aspirate. a case report.
23648935 - State-of-the-art medical prevention of postoperative recurrence of crohn's disease.
4068115 - Malakoplakia of the tongue--a case report.
2839285 - Paget's disease of the male breast.
20234805 - The diagnosis of marburg disease is course-dependent.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Nature reviews. Rheumatology     Volume:  -     ISSN:  1759-4804     ISO Abbreviation:  Nat Rev Rheumatol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500080     Medline TA:  Nat Rev Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Windmill Road, Oxford OX3 7HE, UK. raashid.luqmani@ndorms.ox.ac.uk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anaemia in inflammatory rheumatic diseases.
Next Document:  Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.