| Maintaining monodispersity in a microbubble population formed by flow-focusing. | |
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MedLine Citation:
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PMID: 18205422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dynamic processes impacting the size distributions of lipid-encapsulated microbubbles formed by flow-focusing were observed by video optical microscopy. Parameters studied included the filling gas, gas saturating the surrounding solution, and microbubble size (initial size 2-12 microm) to simulate typical laboratory conditions. Typically, dissolution or growth, followed by Ostwald ripening at a collection cover glass, were observed and quantified. However, in the case of small nitrogen-filled microbubbles surrounded by an air-saturated solution, Ostwald ripening was avoided for at least 9 h. These bubbles had a final size distribution of 1.5 +/- 0.1 microm. This work suggests that lipid-encapsulated microbubbles formed by flow-focusing should be given sufficient time to reach a terminal size before coming into contact with each other. These long-lived mondisperse microbubbles should be of interest in ultrasound contrast agents, microfabrication, food, and research applications. |
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Authors:
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Esra Talu; Kanaka Hettiarachchi; Robert L Powell; Abraham P Lee; Paul A Dayton; Marjorie L Longo |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-01-19 |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: 24 ISSN: 0743-7463 ISO Abbreviation: Langmuir Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-05-27 Revised Date: 2013-02-28 |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
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Languages: eng Pagination: 1745-9 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering and Materials Science, University of California, Davis, Davis, California 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air* Microbubbles* Microfluidic Analytical Techniques / instrumentation, methods Nitrogen / chemistry* Particle Size Viscosity |
| Grant Support | |
ID/Acronym/Agency:
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R21 EB005325/EB/NIBIB NIH HHS; R21 EB005325/EB/NIBIB NIH HHS; R21 EB005325-01/EB/NIBIB NIH HHS; R21 EB005325-02/EB/NIBIB NIH HHS; R21 EB005325-03/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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7727-37-9/Nitrogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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