Document Detail

Maintaining monodispersity in a microbubble population formed by flow-focusing.
MedLine Citation:
PMID:  18205422     Owner:  NLM     Status:  MEDLINE    
The dynamic processes impacting the size distributions of lipid-encapsulated microbubbles formed by flow-focusing were observed by video optical microscopy. Parameters studied included the filling gas, gas saturating the surrounding solution, and microbubble size (initial size 2-12 microm) to simulate typical laboratory conditions. Typically, dissolution or growth, followed by Ostwald ripening at a collection cover glass, were observed and quantified. However, in the case of small nitrogen-filled microbubbles surrounded by an air-saturated solution, Ostwald ripening was avoided for at least 9 h. These bubbles had a final size distribution of 1.5 +/- 0.1 microm. This work suggests that lipid-encapsulated microbubbles formed by flow-focusing should be given sufficient time to reach a terminal size before coming into contact with each other. These long-lived mondisperse microbubbles should be of interest in ultrasound contrast agents, microfabrication, food, and research applications.
Esra Talu; Kanaka Hettiarachchi; Robert L Powell; Abraham P Lee; Paul A Dayton; Marjorie L Longo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-01-19
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  24     ISSN:  0743-7463     ISO Abbreviation:  Langmuir     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-27     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1745-9     Citation Subset:  IM    
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MeSH Terms
Microfluidic Analytical Techniques / instrumentation,  methods
Nitrogen / chemistry*
Particle Size
Grant Support
R21 EB005325/EB/NIBIB NIH HHS; R21 EB005325/EB/NIBIB NIH HHS; R21 EB005325-01/EB/NIBIB NIH HHS; R21 EB005325-02/EB/NIBIB NIH HHS; R21 EB005325-03/EB/NIBIB NIH HHS
Reg. No./Substance:

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