Document Detail

Maintaining differentiated cellular identity.
MedLine Citation:
PMID:  22596319     Owner:  NLM     Status:  In-Data-Review    
Various studies have demonstrated that somatic differentiated cells can be reprogrammed into other differentiated states or into pluripotency, thus showing that the differentiated cellular state is not irreversible. These findings have generated intense interest in the process of reprogramming and in mechanisms that govern the pluripotent state. However, the realization that differentiated cells can be triggered to switch to considerably different lineages also emphasizes that we need to understand how the identity of mature cells is normally maintained. Here we review recent studies on how the differentiated state is controlled at the transcriptional level and discuss how new insights have begun to elucidate mechanisms underlying the stable maintenance of mature cell identities.
Johan Holmberg; Thomas Perlmann
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Publication Detail:
Type:  Journal Article     Date:  2012-05-18
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  13     ISSN:  1471-0064     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  429-39     Citation Subset:  IM    
Ludwig Institute for Cancer Research Ltd, BOX 240, Karolinska Institutet, S-171 77 Stockholm, Sweden; and Department of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3, 171 77 Stockholm, Sweden.
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