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Maintained cerebrovascular function during post-exercise hypotension.
MedLine Citation:
PMID:  23314684     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The post-exercise period is associated with hypotension, and an increased risk of syncope attributed to decreases in venous return and/or vascular resistance. Increased local and systemic vasodilators, sympatholysis, and attenuated baroreflex sensitivity following exercise are also manifest. Although resting cerebral blood flow is maintained, cerebrovascular regulation to acute decreases in blood pressure has not been characterized following exercise. We therefore aimed to assess cerebrovascular regulation during transient bouts of hypotension, before and after 40 min of aerobic exercise at 60 % of estimated maximum oxygen consumption. Beat to beat blood pressure (Finometer), heart rate (ECG), and blood velocity in the middle cerebral artery (MCAv; transcranial Doppler ultrasound) were assessed in ten healthy young humans. The MCAv-mean arterial pressure relationship during a pharmacologically (i.v. sodium nitroprusside) induced transient hypotension was assessed before and at 10, 30, and 60 min following exercise. Despite a significant reduction in mean arterial pressure at 10 min post-exercise (-10 ± 6.9 mmHg; P < 0.05) and end-tidal PCO(2) (10 min post: -2.9 ± 2.6 mmHg; 30 min post: -3.9 ± 3.5 mmHg; 60 min post: -2.7 ± 2.0 mmHg; all P < 0.05), neither resting MCAv nor the cerebrovascular response to hypotension differed between pre- and post-exercise periods (P > 0.05). These data indicate that cerebrovascular regulation remains intact following a moderate bout of aerobic exercise.
Authors:
Christopher K Willie; Philip N Ainslie; Chloe E Taylor; Neil D Eves; Yu-Chieh Tzeng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-12
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, 3333 University Way, Okanagan, Kelowna, BC, Canada, ckwillie@gmail.com.
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