Document Detail

Maintained cardiac output during positive end-expiratory pressure ventilation in open-chest pigs.
MedLine Citation:
PMID:  9181164     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Does ventilation with positive end-expiratory pressure (PEEP) act to reduce cardiac output (CO) not only by impeding venous return but also by inducing myocardial depression? The present study was aimed to demonstrate the possible existence of this latter mechanism. METHODS: Eight pigs of Swedish native breed weighing 20-25 kg and 10-12 weeks old were anaesthetized, tracheotomized and connected to a volume-controlled ventilator. To prevent intrathoracic pressure from interfering with venous return, the heart and juxtacardiac vessels were exposed to atmospheric pressure by opening and retracting the chest and pericardium. Heart rate (HR), CO, stroke volume (SV), mean arterial (MAP), mean right (MRAP) and left (MLAP) atrial pressures were recorded before and after retransfusion of 500 ml of autologous blood. This procedure was carried out twice in each animal-during ventilation with zero and with 15 cm H2O of PEEP. RESULTS: Comparison of the two ventilation modes before volume load revealed negligible differences in HR, CO, SV, MAP, MRAP and MLAP. Moreover, the changes evoked by volume load were practically identical. CONCLUSIONS: Addition of PEEP to regular positive pressure ventilation does not induce any haemodynamically detectable myocardial depression in the piglet.
J E Berglund; E Haldén; S Jakobson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  41     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  618-23     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
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MeSH Terms
Blood Pressure / physiology
Blood Transfusion, Autologous
Cardiac Output / physiology*
Heart Rate / physiology
Intraoperative Period
Positive-Pressure Respiration*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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