Document Detail


Main pulmonary artery dilation in association with congenital bicuspid aortic valve in the absence of pulmonary valve abnormality.
MedLine Citation:
PMID:  20956492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Main pulmonary artery (MPA) dilation is reported to occur in association with pulmonary valve (PV) abnormalities and in genetic diseases of connective tissue. AIM: To determine whether MPA dilation occurs with bicuspid aortic valve (BAV) in the absence of PV abnormality. METHODS: MPA and aortic dimensions were investigated in 194 subjects with BAV and 178 controls matched for age, sex and body surface area (BSA) using transthoracic two-dimensional echocardiography. Using control measurements, linear regression of each parameter versus age, gender, and BSA(2/3) provided expected values. For each subject with BAV, the percentage divergence from expected value ((observed--expected value)/expected value) for each dimension was analysed. RESULTS: MPA and aortic measurements showed normal distribution in all subjects. PV annulus and MPA were larger in BAV; 17.7% positive divergence of MPA dimension from expected was found in diastole, and 16.7% in systole. Aortic dimensions at all levels measured were larger in BAV; divergence was greater distally than proximally (10% divergence at annulus, 31% at ascending aorta). In BAV, divergence of ascending aortic dimensions from expected values increased with age (r(2)=0.142, p=0.02), but MPA divergence from expected values did not increase with age (r(2)=0.001, p=0.296). CONCLUSIONS: MPA dilation occurs in association with BAV in the absence of PV abnormality, suggesting primary vessel wall pathology predisposing to arterial dilation. A systemic abnormality of connective tissue common to both arteries may be responsible, or the dilation may result from a common developmental exposure as both originate from the embryologic cono-truncus.
Authors:
Shelby Kutty; Sheetal Kaul; Christopher J Danford; David A Danford
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1756-61     Citation Subset:  AIM; IM    
Affiliation:
Joint Division of Paediatric Cardiology, University of Nebraska/Creighton University, Children's Hospital and Medical Centre, 8200 Dodge St, Omaha, NE 68114, USA. skutty@unmc.edu
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / pathology,  ultrasonography*
Adolescent
Adult
Aortic Valve / abnormalities*,  pathology
Case-Control Studies
Child
Child, Preschool
Dilatation, Pathologic / ultrasonography
Female
Humans
Infant
Infant, Newborn
Male
Pulmonary Artery / abnormalities*,  pathology,  ultrasonography
Pulmonary Valve / abnormalities
Reference Values
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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