| Main pulmonary artery dilation in association with congenital bicuspid aortic valve in the absence of pulmonary valve abnormality. | |
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MedLine Citation:
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PMID: 20956492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Main pulmonary artery (MPA) dilation is reported to occur in association with pulmonary valve (PV) abnormalities and in genetic diseases of connective tissue. AIM: To determine whether MPA dilation occurs with bicuspid aortic valve (BAV) in the absence of PV abnormality. METHODS: MPA and aortic dimensions were investigated in 194 subjects with BAV and 178 controls matched for age, sex and body surface area (BSA) using transthoracic two-dimensional echocardiography. Using control measurements, linear regression of each parameter versus age, gender, and BSA(2/3) provided expected values. For each subject with BAV, the percentage divergence from expected value ((observed--expected value)/expected value) for each dimension was analysed. RESULTS: MPA and aortic measurements showed normal distribution in all subjects. PV annulus and MPA were larger in BAV; 17.7% positive divergence of MPA dimension from expected was found in diastole, and 16.7% in systole. Aortic dimensions at all levels measured were larger in BAV; divergence was greater distally than proximally (10% divergence at annulus, 31% at ascending aorta). In BAV, divergence of ascending aortic dimensions from expected values increased with age (r(2)=0.142, p=0.02), but MPA divergence from expected values did not increase with age (r(2)=0.001, p=0.296). CONCLUSIONS: MPA dilation occurs in association with BAV in the absence of PV abnormality, suggesting primary vessel wall pathology predisposing to arterial dilation. A systemic abnormality of connective tissue common to both arteries may be responsible, or the dilation may result from a common developmental exposure as both originate from the embryologic cono-truncus. |
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Authors:
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Shelby Kutty; Sheetal Kaul; Christopher J Danford; David A Danford |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 1756-61 Citation Subset: AIM; IM |
Affiliation:
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Joint Division of Paediatric Cardiology, University of Nebraska/Creighton University, Children's Hospital and Medical Centre, 8200 Dodge St, Omaha, NE 68114, USA. skutty@unmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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pathology,
ultrasonography* Adolescent Adult Aortic Valve / abnormalities*, pathology Case-Control Studies Child Child, Preschool Dilatation, Pathologic / ultrasonography Female Humans Infant Infant, Newborn Male Pulmonary Artery / abnormalities*, pathology, ultrasonography Pulmonary Valve / abnormalities Reference Values Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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