| Main antimicrobial components of Tinospora capillipes, and their mode of action against Staphylococcus aureus. | |
| | |
MedLine Citation:
|
PMID: 17692848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this investigation, the antibacterial modes of action of Radix Tinosporae, its major single components, and nine antibiotics with different targets or modes-of-action on Staphylococcus aureus were studied. Metabolic profiles of cultures treated with different medicines were acquired by HPLC/ESI-MS. After HPLC-MS data pretreatment, those profiles acquired were reduced into several MS vectors. Then statistical processing by principal components analysis was carried out upon those vectors, two conclusions could be drawn: (1) the antibacterial mode of action of Radix Tinosporae is similar to that of rifampicin and norfloxacin, which act on nucleic acid; (2) its active components playing main antimicrobial roles on Staphylococcus aureus might be alkaloids, such as palmatine and jatrorrhizine. |
| | |
Authors:
|
Yan Yu; Zhi-biao Yi; Yi-Zeng Liang |
Related Documents
:
|
461188 - Neighbouring group participation in the unblocking of phosphotriesters of nucleic acids. 3017308 - A re-evaluation of evidence attributing the difference in cleavage rates of restriction... 7536958 - Nucleic acid amplification mediated microbial identification. 1569038 - Structural analysis of nucleic acids by precise denaturing gradient gel electrophoresis... 18961898 - Study of liquid-liquid extraction of perrhenate with cyclohexanone in different media. 22170858 - Triterpene acids from rose hip powder inhibit self-antigen- and lps-induced cytokine pr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-01 |
Journal Detail:
|
Title: FEBS letters Volume: 581 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-08-28 Completed Date: 2007-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 4179-83 Citation Subset: IM |
Affiliation:
|
Research Center of Modernization of Chinese Medicines, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
pharmacology* Chromatography, High Pressure Liquid Mass Spectrometry Microbial Sensitivity Tests Plant Extracts / analysis, chemistry, pharmacology Principal Component Analysis Staphylococcus aureus / drug effects* Tinospora / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bioinformatic analysis of post-transcriptional regulation by uORF in human and mouse.
Next Document: Complex formation between recombinant ATP sulfurylase and APS reductase of Allium cepa (L.).