| Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster. | |
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MedLine Citation:
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PMID: 20045686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During Drosophila melanogaster oogenesis, a germline stem cell divides forming a cyst of 16 interconnected cells. One cell enters the oogenic pathway, and the remaining 15 differentiate as nurse cells. Although directed transport and localization of oocyte differentiation factors within the single cell are indispensible for selection, maintenance, and differentiation of the oocyte, the mechanisms regulating these events are poorly understood. Mago Nashi and Tsunagi/Y14, core components of the exon junction complex (a multiprotein complex assembled on spliced RNAs), are essential for restricting oocyte fate to a single cell and for localization of oskar mRNA. Here we provide evidence that Mago Nashi and Tsunagi/Y14 form an oogenic complex with Ranshi, a protein with a zinc finger-associated domain and zinc finger domains. Genetic analyses of ranshi reveal that (1) 16-cell cysts are formed, (2) two cells retain synaptonemal complexes, (3) all cells have endoreplicated DNA (as observed in nurse cells), and (4) oocyte-specific cytoplasmic markers accumulate and persist within a single cell but are not localized within the posterior pole of the presumptive oocyte. Our results indicate that Ranshi interacts with the exon junction complex to localize components essential for oocyte differentiation within the posterior pole of the presumptive oocyte. |
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Authors:
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Jordan P Lewandowski; Kathy B Sheehan; Paul E Bennett; Robert E Boswell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-04 |
Journal Detail:
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Title: Developmental biology Volume: 339 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-05-24 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 307-19 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Cell and Molecular Biology Graduate Program, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Carrier Proteins / genetics, metabolism* Cell Differentiation Drosophila Proteins / genetics, metabolism* Drosophila melanogaster / metabolism* Genes, Insect Nuclear Proteins / genetics, metabolism* Oocytes / cytology*, metabolism Oogenesis / physiology* Phenotype RNA-Binding Proteins / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM57989/GM/NIGMS NIH HHS; R01 GM057989-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Drosophila Proteins; 0/Mago protein, Drosophila; 0/Nuclear Proteins; 0/RNA-Binding Proteins; 0/ranshi protein, Drosophila; 0/tsunagi protein, Drosophila |
| Comments/Corrections | |
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