| Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells. | |
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MedLine Citation:
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PMID: 20162409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnolol inhibited proliferation of human malignant melanoma A375-S2 cells. The drug induced oligonucleosomal fragmentation of DNA in A375-S2 cells and increased caspase-3, 8, 9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase dependent DNase (ICAD) and poly-(ADP-ribose) polymerase (PARP). Pan-caspase inhibitor (z-VADfmk), caspase-3 inhibitor (z-DEVD-fmk), capase-8 inhibitor (z-IETD-fmk), caspase-9 inhibitor (z-LEHD-fmk) and caspase-10 inhibitor (z-AEVD-fmk) inhibited magnolol-induced A375-S2 cell apoptosis. The level of anti-apoptotic mitochondrial protein Bcl-2 was up-regulated while the level of pro-apoptotic protein Bax was down-regulated. Taken together, our results indicate that magnolol induces apoptosis by activation of both mitochondrial and death receptor pathways in A375-S2 cells. |
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Authors:
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Qingjun You; Mingqiu Li; Guoqing Jiao |
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Publication Detail:
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Type: Journal Article Date: 2010-02-17 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 32 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 1789-94 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Wuxi The Forth Hospital, Wuxi City Huihe Road 200, 214062, Wuxi, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD95
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immunology Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis / drug effects* Biphenyl Compounds / pharmacology* Bisbenzimidazole Blotting, Western Caspase 3 / metabolism Caspase 8 / metabolism Caspase 9 / metabolism Cell Line, Tumor Cell Nucleus / drug effects, ultrastructure Cell Survival / drug effects Coloring Agents DNA Fragmentation DNA, Neoplasm / chemistry, drug effects, isolation & purification Humans Lignans / pharmacology* Melanoma, Experimental / drug therapy, pathology Mitochondria / drug effects* Proto-Oncogene Proteins c-bcl-2 / physiology Receptors, Death Domain / agonists* Signal Transduction / drug effects bcl-2-Associated X Protein / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Antineoplastic Agents, Phytogenic; 0/Biphenyl Compounds; 0/Coloring Agents; 0/DNA, Neoplasm; 0/Lignans; 0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Death Domain; 0/bcl-2-Associated X Protein; 23491-44-3/Bisbenzimidazole; 528-43-8/magnolol; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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