Document Detail

Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum.
MedLine Citation:
PMID:  18484527     Owner:  NLM     Status:  MEDLINE    
Magnolia officinalis is a commonly used traditional Chinese medicine for treating gastrointestinal disorders. HPLC quantification analysis revealed that magnolol and honokiol were the most abundant constituents of M. officinalis extracts, with their contents in the ethanol extract being the highest, the water extract the least and the 50 % ethanol extract in between. In guinea pig isolated ileum, both magnolol and honokiol inhibited contraction to acetylcholine. The herbal extracts also produced inhibitory responses, in an order of decreasing efficacy: ethanol extract > 50 % ethanol extract > water extract. The differences in inhibitory efficacies among the three extracts were similar to the differences in their magnolol and honokiol contents. Further examination demonstrated that two mixtures containing solely magnolol and honokiol at concentrations identical to those determined in the ethanol and water extracts exhibited similar levels of anti-spasmodic effects as their respective extracts while a "blank" ethanol extract free of magnolol and honokiol failed to produce any response. These observations suggest that the magnolol and honokiol contents account for the anti-spasmodic effects of M. officinalis extracts in guinea pig isolated ileum.
Sunny Sun-Kin Chan; Ming Zhao; Lixing Lao; Harry H Fong; Chun-Tao Che
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Planta medica     Volume:  74     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  IM    
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China.
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MeSH Terms
Biphenyl Compounds / chemistry,  pharmacology*
Guinea Pigs
Ileum / drug effects*
Lignans / chemistry,  pharmacology*
Magnolia / chemistry*
Molecular Structure
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects
Plant Extracts / chemistry,  pharmacology
Grant Support
Reg. No./Substance:
0/Biphenyl Compounds; 0/Lignans; 0/Plant Extracts; 35354-74-6/honokiol; 528-43-8/magnolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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