| Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees: a case-control study. | |
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MedLine Citation:
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PMID: 11153815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case-control study was performed to clarify the cause of ischemic heart disease (IHD), such as acute myocardial infarction and angina pectoris, in Japanese employees. Among 122,051 workers from 31 industries, 94 cases of IHD were the subjects of the study, and a total of 191 age-matched subjects from the same department, but who did not develop IHD, served as the controls. Compared with the control group, body mass index, blood pressure, fasting plasma glucose, serum total cholesterol and serum triglyceride were significantly higher, and cigarette consumption and serum uric acid also tended to be higher, in the patient group from at least 10 years prior to onset. The frequency of moderate-drinkers tended to be lower in the case group. Electrocardiograms showed that, compared with the control group, the frequency of myocardial ischemia was higher in the case group from 9 years prior to onset and further rapidly increased from 3 years prior. The frequency of subjects with arrhythmia was the same as the control group until 3 years before onset and increased rapidly from 2 years prior. The frequency of subjects with multiple risk factors, particularly obesity, hypertension, hyperlipidemia and hyperglycemia, was consistently higher in the case group compared with the control group from 10 years prior to onset. Conditional logistic regression analysis demonstrated that having more than one risk factor greatly increased the risk; in particular, the combination of 3 or more factors increased the relative risk to 10.56 (95% confidence interval: 3.30-33.78). These findings suggest that a long duration of multiple risks is involved in the onset of IHD in Japanese employees, and that annual ECG monitoring as part of the medical examination was important in the prognosis. |
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Authors:
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T Nakamura; Y Tsubono; K Kameda-Takemura; T Funahashi; S Yamashita; S Hisamichi; T Kita; T Yamamura; Y Matsuzawa; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese circulation journal Volume: 65 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-10 Completed Date: 2001-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: Australia |
Other Details:
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Languages: eng Pagination: 11-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Female Humans Incidence Japan / epidemiology Male Middle Aged Myocardial Ischemia / epidemiology, etiology* Occupational Diseases / epidemiology*, etiology Odds Ratio Regression Analysis Retrospective Studies Risk Factors Time Factors |
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