Document Detail

Magnitude and prognosis associated with ventricular arrhythmias in patients hospitalized with acute coronary syndromes (from the GRACE Registry).
MedLine Citation:
PMID:  19064008     Owner:  NLM     Status:  MEDLINE    
The incidence, prognosis, and factors associated with ventricular arrhythmia (VA) in acute coronary syndrome are unknown. We sought to examine the magnitude, predictors, and outcomes of in-hospital VA in patients with acute coronary syndrome. The population comprised 52,380 patients enrolled in the Global Registry of Acute Coronary Events from 1999 to 2005. The proportion who developed VA during hospitalization was 6.9% (1.8% with ventricular tachycardia, 5.1% with ventricular fibrillation or cardiac arrest). The incidence of in-hospital VA decreased over time (8.0% in 1999, 7.0% in 2002, 5.8% in 2005, p <0.001). In-hospital case-fatality rates were higher in patients with versus those without VA (52% vs 1.6%). Several demographic and clinical variables were associated with the occurrence of VA including ST deviation, Killip class, age, initial cardiac markers, serum creatinine and heart rate, and history of selected co-morbidities. Six-month postdischarge mortality was higher in survivors of in-hospital VA versus those who did not develop VA during hospitalization (odds ratio 1.57, 95% confidence interval 1.27 to 1.95). In conclusion, development of VA during hospitalization for acute coronary syndrome was associated with higher in-hospital and 6-month mortalities.
Alvaro Avezum; Leopoldo S Piegas; Robert J Goldberg; David Brieger; Martin K Stiles; Richard Paolini; Wei Huang; Joel M Gore;
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-10-23
Journal Detail:
Title:  The American journal of cardiology     Volume:  102     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-09     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1577-82     Citation Subset:  AIM; IM    
Dante Pazzanese Institute of Cardiology, Research Division, São Paulo, São Paulo, Brazil.
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MeSH Terms
Acute Coronary Syndrome / complications*,  mortality
Heart Arrest / epidemiology,  etiology
Hospital Mortality
Kaplan-Meiers Estimate
Logistic Models
Middle Aged
Prospective Studies
Tachycardia, Ventricular / epidemiology,  etiology*
Ventricular Fibrillation / epidemiology,  etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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