Document Detail

Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross-sectional study.
MedLine Citation:
PMID:  20180959     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Adequate antiretroviral drug potency is essential for obtaining therapeutic benefit, however, the behavioral aspects of proper adherence and readiness to medication, often determine therapeutic outcome. Therefore, this study aimed to assess the level and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy (HAART) among people living with HIV/AIDS (PLWHA) at Gondar University Teaching Hospital and Felege Hiwot Hospital in Northwest Ethiopia. METHODS: A cross-sectional study was conducted between July and September 2008 using structured interviewer-administered questionnaire. All consecutive adult outpatients who were receiving antiretroviral treatment for at least three months, seen at both hospitals during the study period and able to give informed consent were included in the study. Multivariate logistic regression was used to determine factors associated with nonadherence and nonreadiness. RESULTS: A total of 504 study subjects were included in this study. The prevalence rates of nonadherence and nonreadiness to HAART were 87 (17.3%) and 70 (13.9%) respectively. Multivariate logistic regression analysis revealed that medication adverse effects, nonreadiness to HAART, contact with psychiatric care service and having no goal had statistically significant association with nonadherence. Moreover, unwillingness to disclose HIV status was significantly associated with nonreadiness to HAART. CONCLUSIONS: In this study the level of nonadherence and nonreadiness to HAART seems to be encouraging. Several factors associated with nonadherance and nonreadiness to HAART were identified. Efforts to minimize nonadherence and nonreadiness to HAART should be integrated in to regular clinical follow up of patients.
Belay Tessema; Fantahun Biadglegne; Andargachew Mulu; Assefa Getachew; Frank Emmrich; Ulrich Sack
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Publication Detail:
Type:  Journal Article     Date:  2010-01-14
Journal Detail:
Title:  AIDS research and therapy     Volume:  7     ISSN:  1742-6405     ISO Abbreviation:  AIDS Res Ther     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-05-20     Revised Date:  2010-09-30    
Medline Journal Info:
Nlm Unique ID:  101237921     Medline TA:  AIDS Res Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  2     Citation Subset:  -    
Department of Medical Laboratory Technology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
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