| Magnitude and Variability of the Glucagon-Like Peptide-1 Response in Patients With Type 2 Diabetes Up to 2 Years Following Gastric Bypass Surgery. | |
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MedLine Citation:
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PMID: 22124715 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVETo characterize the magnitude and variance of the change of glucose and glucagon-like peptide-1 (GLP-1) concentrations, and to identify determinants of glucose control up to 2 years after gastric bypass (GBP).RESEARCH DESIGN AND METHODSGlucose and GLP-1 concentrations were measured during an oral glucose challenge before and 1, 12, and 24 months after GBP in 15 severely obese patients with type 2 diabetes.RESULTSGlucose area under the curve from 0 to 180 min (AUC(0-180)) started decreasing in magnitude (P < 0.05) 1 month after surgery. GLP-1 AUC(0-180) increased in magnitude 1 month after GBP (P < 0.05), with increased variance only after 1 year (P(σ)(2) ≤ 0.001). GLP-1 AUC(0-180) was positively associated with insulin AUC(0-180) (P = 0.025).CONCLUSIONSThe increase in variance of GLP-1 at 1 and 2 years after GBP suggests mechanisms other than proximal gut bypass to explain the enhancement of GLP-1 secretion. The association between GLP-1 and insulin concentrations supports the idea that the incretins are involved in glucose control after GBP. |
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Authors:
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Bart J Van der Schueren; Peter Homel; Mariam Alam; Keesandra Agenor; Gary Wang; David Reilly; Blandine Laferrère |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-28 |
Journal Detail:
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Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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New York Obesity Nutrition Research Center, St. Luke's Roosevelt Hospital Center, New York, New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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