Document Detail


Magnetorelaxometric quantification of magnetic nanoparticles in an artery model after ex vivo magnetic drug targeting.
MedLine Citation:
PMID:  19700820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In magnetic drug targeting a chemotherapeutic agent is bound to coated magnetic nanoparticles, which are administered to the blood vessel system and subsequently focused by an external applied magnetic field. The optimization of intra-arterial magnetic drug targeting (MDT) requires detailed knowledge about the biodistribution of particles in the artery and the respective surrounding after the application. Here, we demonstrate the potential of magnetorelaxometry for quantifying the distribution of magnetic nanoparticles in the artery. To this end, we present a magnetorelaxometry investigation of a MDT study in an artery model. In particular, the absolute magnetic nanoparticle accumulation along the artery as well as the uptake profile along the region around the MDT-magnet position was quantified.
Authors:
H Richter; F Wiekhorst; K Schwarz; S Lyer; R Tietze; Ch Alexiou; L Trahms
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-21
Journal Detail:
Title:  Physics in medicine and biology     Volume:  54     ISSN:  0031-9155     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-02     Completed Date:  2009-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  N417-24     Citation Subset:  IM    
Affiliation:
Physikalisch-Technische Bundesanstalt, Berlin, Germany. heike.richter@ptb.de
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MeSH Terms
Descriptor/Qualifier:
Arteries / chemistry*
Drug Delivery Systems / methods*
Magnetics / methods*
Metal Nanoparticles / analysis*
Reproducibility of Results
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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