| Magnetorelaxometric quantification of magnetic nanoparticles in an artery model after ex vivo magnetic drug targeting. | |
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MedLine Citation:
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PMID: 19700820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In magnetic drug targeting a chemotherapeutic agent is bound to coated magnetic nanoparticles, which are administered to the blood vessel system and subsequently focused by an external applied magnetic field. The optimization of intra-arterial magnetic drug targeting (MDT) requires detailed knowledge about the biodistribution of particles in the artery and the respective surrounding after the application. Here, we demonstrate the potential of magnetorelaxometry for quantifying the distribution of magnetic nanoparticles in the artery. To this end, we present a magnetorelaxometry investigation of a MDT study in an artery model. In particular, the absolute magnetic nanoparticle accumulation along the artery as well as the uptake profile along the region around the MDT-magnet position was quantified. |
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Authors:
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H Richter; F Wiekhorst; K Schwarz; S Lyer; R Tietze; Ch Alexiou; L Trahms |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-21 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 54 ISSN: 0031-9155 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: N417-24 Citation Subset: IM |
Affiliation:
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Physikalisch-Technische Bundesanstalt, Berlin, Germany. heike.richter@ptb.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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chemistry* Drug Delivery Systems / methods* Magnetics / methods* Metal Nanoparticles / analysis* Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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