Document Detail


Magnetoencephalography in partial epilepsy: clinical yield and localization accuracy.
MedLine Citation:
PMID:  9382474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The goals of this study were to determine (1) the yield of magnetoencephalography (MEG) according to epilepsy type, (2) if MEG spike sources colocalize with focal epileptogenic pathology, and (3) if MEG can identify the epileptogenic zone when scalp ictal electroencephalogram (EEG) or magnetic resonance imaging (MRI) fail to localize it. Twenty-two patients with mesial temporal (10 patients), neocortical temporal (3 patients), and extratemporal lobe epilepsy (9 patients) were studied. A 37-channel biomagnetometer was used for simultaneously recording MEG with EEG. During the typical 2-3-hour MEG recording session, interictal epileptiform activity was observed in 16 of 22 patients. MEG localization yield was greater in patients with neocortical epilepsy (92%) than in those with mesial temporal lobe epilepsy (50%). In 5 of 6 patients with focal epileptogenic pathology, MEG spike sources were colocalized with the lesions. In 11 of 12 patients with nonlocalizing (ambiguous abnormalities or normal) MRI, MEG spike sources were localized in the region of the epileptogenic zone as ultimately defined by all clinical and EEG information (including intracranial EEG). In conclusion, MEG can reliably localize sources of spike discharges in patients with temporal and extratemporal lobe epilepsy. MEG sometimes provides noninvasive localization data that are not otherwise available with MRI or conventional scalp ictal EEG.
Authors:
R C Knowlton; K D Laxer; M J Aminoff; T P Roberts; S T Wong; H A Rowley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  42     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-07     Completed Date:  1997-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  622-31     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of California School of Medicine, San Francisco 94143-0628, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Electroencephalography
Epilepsies, Partial / physiopathology*,  radionuclide imaging*
Female
Humans
Magnetic Resonance Imaging
Magnetoencephalography*
Male
Middle Aged
Tomography, Emission-Computed
Grant Support
ID/Acronym/Agency:
R01-NS31966-01/NS/NINDS NIH HHS

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