Document Detail

Magnetoencephalographic studies of focal epileptic activity in three patients with epilepsy suggestive of Lennox-Gastaut syndrome.
MedLine Citation:
PMID:  17525026     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the electromagnetic sources of localized epileptic activities using magnetoencephalography (MEG) in three adult patients with epilepsy suggestive of Lennox-Gastaut syndrome (LGS). METHODS: MEG and simultaneous electroencephalography (EEG) were recorded from three adult patients using a 204-channel, whole-head MEG system. Equivalent current dipoles (ECDs) were calculated for epileptic spikes on MEG according to the single dipole model. RESULTS: In two patients, MEG showed epileptiform discharges restricted to the unilateral temporal area, corresponding to the EEG spikes. The ECDs calculated from these MEG spikes were clustered in the unilateral temporal lobe. In our third patient, MEG spikes appeared in the right centroparietal area; ECDs were located to the right parietal lobe. CONCLUSIONS: The sources of epileptiform discharges that were detected in a restricted area were localized to specific parts of the brain cortex. Despite certain limitations (small number of patients; atypical late-onset epilepsy in one) our study suggests that MEG may prove to be a useful tool for investigating electromagnetic features of localized epileptic discharges in patients with LGS. Based on these preliminary results, further studies performed in patients with typical LGS features are justified.
Kotaro Sakurai; Naoaki Tanaka; Kyousuke Kamada; Fumiya Takeuchi; Youji Takeda; Tsukasa Koyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  9     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-25     Completed Date:  2007-09-06     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  158-63     Citation Subset:  IM    
Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Brain Mapping / methods
Cerebral Cortex / physiopathology*
Diagnosis, Differential
Electroencephalography / statistics & numerical data
Epilepsies, Partial / diagnosis*,  physiopathology
Epilepsy / diagnosis*,  physiopathology
Functional Laterality
Magnetoencephalography / statistics & numerical data*
Mental Retardation / diagnosis,  physiopathology

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