Document Detail

Magnetoencephalographic gamma power reduction in patients with schizophrenia during resting condition.
MedLine Citation:
PMID:  19288463     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The "default network" represents a baseline condition of brain function and is of interest in schizophrenia research because its component brain regions are believed to be aberrant in the disorder. We hypothesized that magnetoencephalographic (MEG) source localization analysis would reveal abnormal resting activity within particular frequency bands in schizophrenia.
EXPERIMENTAL DESIGN: Eyes-closed resting state MEG signals were collected for two comparison groups. Patients with schizophrenia (N = 38) were age-gender matched with healthy control subjects (N = 38), and with a group of unmedicated unaffected siblings of patients with schizophrenia (N = 38). To localize 3D-brain regional differences, synthetic aperture magnetometry was calculated across established frequency bands as follows: delta (0.9-4 Hz), theta (4-8 Hz), alpha (8-14 Hz), beta (14-30 Hz), gamma (30-80 Hz), and super-gamma (80-150 Hz). PRINCIPLE OBSERVATIONS: Patients with schizophrenia showed significantly reduced activation in the gamma frequency band in the posterior region of the medial parietal cortex. As a group, unaffected siblings of schizophrenia patients also showed significantly reduced activation in the gamma bandwidth across similar brain regions. Moreover, using the significant region for the patients and examining the gamma band power gave an odds ratio of 6:1 for reductions of two standard deviations from the mean. This suggests that the measure might be the basis of an intermediate phenotype.
CONCLUSIONS: MEG resting state analysis adds to the evidence that schizophrenic patients experience this condition very differently than healthy controls. Whether this baseline difference relates to network abnormalities remains to be seen.
Lindsay Rutter; Frederick W Carver; Tom Holroyd; Sreenivasan Rajamoni Nadar; Judy Mitchell-Francis; Jose Apud; Daniel R Weinberger; Richard Coppola
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Human brain mapping     Volume:  30     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-11-30     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3254-64     Citation Subset:  IM    
MEG Core Facility, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Brain / pathology,  physiopathology*
Brain Mapping*
Case-Control Studies
Imaging, Three-Dimensional / methods
Magnetoencephalography / methods*
Rest / physiology*
Schizophrenia / physiopathology*
Grant Support
Z01 MH002889-01/MH/NIMH NIH HHS; Z01 MH002890-01/MH/NIMH NIH HHS

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