Document Detail

Magnetocardiographic mapping of QRS fragmentation in patients with a history of malignant tachyarrhythmias.
MedLine Citation:
PMID:  11594414     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The identification of patients at increased risk for ventricular tachycardia or ventricular fibrillation (VT/VF) and sudden cardiac death has consequences for therapeutic options and thus may reduce mortality in patients with coronary artery disease (CAD). HYPOTHESIS: We hypothesized that the intra-QRS fragmentation in magnetocardiographic recordings is increased in patients with CAD and with a history of VT/VF. METHODS: Multichannel magnetocardiography (MCG) was carried out in 34 healthy controls, 42 patients with CAD without a history of VT/VF, and 43 patients with CAD and with a history of VT/VF. The intra-QRS fragmentation was quantified by a new fragmentation score. Its spatial distribution was investigated using two-dimensional (2-D) contour maps according to the sensor position of the 49-channel magnetogradiometer. RESULTS: Patients with CAD and with a history of VT/VF had significantly increased QRS fragmentation compared with patients with CAD without VT/VF or controls (72.9+/-37.5, 48.5+/-14.3, and 42.5+/-7.8, respectively: p <0.05). The area of high fragmentation in 2-D contour maps was twice as large in patients with than in those without a history of VT/VF (represented by the number of MCG channels with high fragmentation: 26.3+/-15.5 vs. 12.4+/-9.9, p<0.0001). Patients prone to VT/VF could be identified with a sensitivity of 64% and a specificity of 90%. CONCLUSION: In patients with CAD and with a history of VT/VF, intra-QRS fragmentation is increased and the area of high fragmentation in 2-D contour maps is enlarged. These findings may be helpful in identifying patients with CAD at risk for malignant tachyarrhythmias.
P Gödde; R Agrawal; H P Müller; K Czerski; P Endt; U Steinhoff; M Oeff; H P Schultheiss; S Behrens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  24     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-11     Completed Date:  2002-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  682-8     Citation Subset:  IM    
University Clinic Benjamin Franklin, Free Berlin University, 2nd Medical Clinic, Department of Cardiology and Pulmonary Disease, Berlin, Germany.
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MeSH Terms
Coronary Disease / complications
Electrophysiologic Techniques, Cardiac*
Middle Aged
Signal Processing, Computer-Assisted*
Tachycardia / complications,  physiopathology*
Ventricular Fibrillation / complications,  physiopathology*

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