| Magnetocardiographic mapping of QRS fragmentation in patients with a history of malignant tachyarrhythmias. | |
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MedLine Citation:
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PMID: 11594414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The identification of patients at increased risk for ventricular tachycardia or ventricular fibrillation (VT/VF) and sudden cardiac death has consequences for therapeutic options and thus may reduce mortality in patients with coronary artery disease (CAD). HYPOTHESIS: We hypothesized that the intra-QRS fragmentation in magnetocardiographic recordings is increased in patients with CAD and with a history of VT/VF. METHODS: Multichannel magnetocardiography (MCG) was carried out in 34 healthy controls, 42 patients with CAD without a history of VT/VF, and 43 patients with CAD and with a history of VT/VF. The intra-QRS fragmentation was quantified by a new fragmentation score. Its spatial distribution was investigated using two-dimensional (2-D) contour maps according to the sensor position of the 49-channel magnetogradiometer. RESULTS: Patients with CAD and with a history of VT/VF had significantly increased QRS fragmentation compared with patients with CAD without VT/VF or controls (72.9+/-37.5, 48.5+/-14.3, and 42.5+/-7.8, respectively: p <0.05). The area of high fragmentation in 2-D contour maps was twice as large in patients with than in those without a history of VT/VF (represented by the number of MCG channels with high fragmentation: 26.3+/-15.5 vs. 12.4+/-9.9, p<0.0001). Patients prone to VT/VF could be identified with a sensitivity of 64% and a specificity of 90%. CONCLUSION: In patients with CAD and with a history of VT/VF, intra-QRS fragmentation is increased and the area of high fragmentation in 2-D contour maps is enlarged. These findings may be helpful in identifying patients with CAD at risk for malignant tachyarrhythmias. |
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Authors:
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P Gödde; R Agrawal; H P Müller; K Czerski; P Endt; U Steinhoff; M Oeff; H P Schultheiss; S Behrens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical cardiology Volume: 24 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2002-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 682-8 Citation Subset: IM |
Affiliation:
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University Clinic Benjamin Franklin, Free Berlin University, 2nd Medical Clinic, Department of Cardiology and Pulmonary Disease, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Coronary Disease / complications Electrocardiography* Electrophysiologic Techniques, Cardiac* Female Humans Magnetics Male Middle Aged Signal Processing, Computer-Assisted* Tachycardia / complications, physiopathology* Ventricular Fibrillation / complications, physiopathology* |
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