Document Detail

Magnetocardiographic differences of ventricular repolarization parameters between Wistar rats and guinea pigs.
MedLine Citation:
PMID:  16012644     Owner:  NLM     Status:  MEDLINE    
The morphology and range of duration of the action potential (AP) in normal Wistar rat's (WR) myocyte markedly differ from those of guinea pigs (GP), whose plateau (phase 2) duration is longer. Thus a clear-cut T wave can be easy defined in GP but not in WR. Aim of this study was to differentiate magnetocardiographic (MCG) ventricular repolarization (VR) parameters of healthy adult WR and GP. METHODS: 10 female animals (5 Guinea pigs and 5 Wistar rats) were studied with a 36-channel MCG system (sensitivity of 20 fT/square root of Hz1/2) and with one ECG lead, in an unshielded hospital room. To assess VR, HR-corrected, JTpeak, JTend, Tpeak-end and QTend, intervals were measured from both MCG waveforms. Timing was improved by MCG maps analysis. Magnetic field orientation (MFO), its dynamics (MFD) and stability (JTS) during the JT interval, were also automatically computed from MCG maps. RESULTS: All repolarization intervals were significantly shorter in WR than in GP, except the Tpeak-end, which was longer. MFO and MFD also differed. CONCLUSIONS: MCG estimate of VR parameters, in adult WR and GP, is precise enough to evidence breed-related differences, consistent with physiological heterogeneity of duration during phases 2 and 3 of the AP, and with an higher degree of transmural dispersion of repolarization in WR.
D Brisinda; A M Meloni; R Fenici
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-30
Journal Detail:
Title:  Neurology & clinical neurophysiology : NCN     Volume:  2004     ISSN:  1526-8748     ISO Abbreviation:  Neurol Clin Neurophysiol     Publication Date:  2004  
Date Detail:
Created Date:  2005-07-13     Completed Date:  2006-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100972440     Medline TA:  Neurol Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9     Citation Subset:  IM    
Clinical Physiology-Biomagnetism Center, Catholic University of Sacred Heart, Rome, Italy.
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MeSH Terms
Body Surface Potential Mapping / methods
Electrocardiography / methods*
Guinea Pigs
Heart Conduction System / physiology*
Rats, Wistar
Species Specificity
Ventricular Function / physiology*

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